Review ArticleNoncoding RNAs in Calcific Aortic Valve Disease: A Review of Recent StudiesNi, Wen-Juan MA*; Wu, Ying-Zhong BS†; Ma, Dong-Hong PhD‡; Leng, Xiao-Min PhD*Author Information *Henan Key Laboratory of Neural Regeneration, Department of Neurology, The First Affiliated Hospital of XinXiang Medical University, XinXiang, P. R. China; †XinXiang Medical University, XinXiang, P. R. China; and ‡Department of Nephrology, The First Affiliated Hospital of XinXiang Medical University, XinXiang, P. R. China. Reprints: Xiao-Min Leng, PhD, Henan Key Laboratory of Neural Regeneration, Department of Neurology, The First Affiliated Hospital of XinXiang Medical University, JianKang Rd 88, WeiHui 453100, XinXiang, Henan, P. R. China (e-mail: [email protected]). Wen-Juan Ni was funded by the First Affiliated Hospital of XinXiang Medical University Youth Fund (QN-2017-A009). Xiao-Min Leng was funded by the First Affiliated Hospital of XinXiang Medical University (xyyfy2014BS-006) and Henan Educational Administration (16B320014). Wen-Juan Ni and Xiao-Min Leng contributed to the conception of the study. Wen-Juan Ni and Xiao-Min Leng wrote the manuscript. Wen-Juan Ni and Ying-Zhong Wu drafted all the tables. Wen-Juan Ni and Xiao-Min Leng drafted all the pictures. Wen-Juan Ni, Dong-Hong Ma and Xiao-Min Leng discussed and improved the revised manuscript. Xiao-Min Leng submitted the manuscript. The authors report no conflict of interests. Journal of Cardiovascular Pharmacology: May 2018 - Volume 71 - Issue 5 - p 317-323 doi: 10.1097/FJC.0000000000000569 Buy Metrics Abstract Calcific aortic valve disease (CAVD) is the most common heart valve disorder in human populations. Nevertheless, there are presently no effective means for its prevention and treatment. It is therefore critical to comprehensively define key mechanisms of the disease. A major focus of cardiovascular research has been characterization of how regulation of gene expression maintains healthy physiologic status of the component tissues of the system and how derangements of gene regulation may become pathological. Recently, substantial evidence has emerged that noncoding RNAs, which are an enormous and versatile class of regulatory elements, such as microRNAs and long noncoding RNAs, have roles in onset and prognosis of CAVD. Authors of the present report have therefore here provided a summary of the current understanding of contributions made by noncoding RNAs major features of CAVD. It is anticipated that this article will serve as a valuable guide to research strategy in this field and may additionally provide both researchers and clinicians with an expanded range of CAVD-associated biomarkers. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.