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Factors Influencing Various Aspects of Patients' Knowledge of Oral Anticoagulation

Pourafkari, Leili, MD, FACC, FASE*,†; Baghbani-Oskouei, Aidin, MD*; Taban-Sadeghi, Mohammadreza, MD*; Salamzadeh, Vida, MD*; Ghaffari, Samad, MD, FACC*; Savadi-Oskouei, Safa, MD*; Nader, Nader, D., MD, PhD, FACC, FCCP


In the article that appears on pages 174 to 179 of the March 2018 issue of Journal of Cardiovascular Pharmacology , Aidin Baghbani-Oskouei’s affiliation was listed incorrectly. The correct affiliation is Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Cardiovascular Pharmacology. 72(3):165, September 2018.

Journal of Cardiovascular Pharmacology: March 2018 - Volume 71 - Issue 3 - p 174–179
doi: 10.1097/FJC.0000000000000558
Original Article

Objectives: To identify and examine individual characteristics and socioeconomic factors that contribute to the knowledge of patients who receive warfarin anticoagulation.

Methods: All patients treated using warfarin for anticoagulation were enrolled during a 6-month period at a university-affiliated cardiac clinic. All relevant demographic and clinical information were collected and the Anticoagulation Knowledge Assessment (AKA) questionnaire consisting of 29 questions was administered. After completion, the questionnaires were scored and the percent correct answers were analyzed for overall scores, as well as the following categories: drug/food interactions, pharmacological knowledge, recognition of complications, and patient compliance. Multiple linear regression analysis was used to identify the contributing factors to the knowledge level of the patients in each category.

Results: One hundred fifty patients (79 men and 71 women) with a median age of 61.5 years completed the AKA questionnaire. The average overall score was 29.3%. Living alone (P = 0.008), higher levels of education (P = 0.001), and durations of ≥3 years of warfarin therapy (P = 0.018) positively impacted overall AKA scores.

Conclusions: Socioeconomic factors and level of general education remain the most important elements determining the patient awareness of therapeutic goals, possible drug/food interaction, recognition of adverse effects, and compliance of warfarin treatment.

*Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; and

Department of Anesthesiology, University at Buffalo, Buffalo, NY.

Reprints: Nader D. Nader, MD, PhD, FACC, FCCP, Department of Anesthesiology, 77 Goodell Suite #550, Buffalo, NY 14203 (e-mail:

The authors report no conflicts of interest.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (

Received October 18, 2017

Accepted November 30, 2017

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