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Does Aldosterone Play a Significant Role for Regulation of Vascular Tone?

Lyngsø, Kristina S.; Assersen, Kasper; Dalgaard, Emil G.; Skott, Ole; Jensen, Boye L.; Hansen, Pernille B. L. PhD

Journal of Cardiovascular Pharmacology: July 2016 - Volume 68 - Issue 1 - p 1–10
doi: 10.1097/FJC.0000000000000345
Invited Review Article

Abstract: Besides the well-known renal effects of aldosterone, the hormone is now known to have direct vascular effects. Clinical observations underline substantial adverse effects of aldosterone on cardiovascular function. The source of systemic circulating aldosterone is the adrenal gland zona glomerulosa cells through stimulus-secretion coupling involving depolarization, opening of L- and T-type calcium channels and aldosterone synthase activation. Local formation and release in peripheral tissues such as perivascular fat is recognized. Where does aldosterone affect the vasculature? Mineralocorticoid receptors (MRs) are present in endothelial and vascular smooth muscle cells, and MR-independent pathways are also involved. The vascular effects of aldosterone are complex, both concentration and temporal and spatial aspects are relevant. The acute response includes vasodilation through endothelial nitric oxide formation and vasoconstrictor effects through endothelial-contracting cyclooxygenase-derived factors and a changed calcium handling. The response to aldosterone can change within the same blood vessels depending on the exposure time and status of the endothelium. Chronic responses involve changed levels of reactive oxygen radicals, endothelial Na-influx and smooth muscle calcium channel expression. Furthermore, perivascular cells for example mast cells have also been suggested to participate in the chronic response. Moreover, the vascular effect of aldosterone depends on the status of the endothelium which is likely the cause of the very different responses to aldosterone and MR treatment observed in human studies going from increased to decreased flow depending on whether the patient had prior cardiovascular disease with endothelial dysfunction or not. A preponderance of constrictor versus dilator responses to aldosterone could therefore be involved in the detrimental vascular actions of the hormone in the setting of endothelial dysfunction and contribute to explain the beneficial action of MR blockers on blood pressure and target organ injury.

Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, DK Odense C, Denmark.

Reprints: Pernille B. L. Hansen, PhD, Department of Cardiovascular and Renal Research, University of Southern Denmark, Winsloewparken 21,3, 5000 Odense C, Denmark (e-mail:

Supported by grants from the Danish Medical Research Council (11-107552), The Danish Heart Foundation (11-04-R84-A3492-22663). Furthermore, we would like to thank ADMIRE COST for support.

The authors report no conflicts of interest.

Received August 16, 2015

Accepted November 11, 2015

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