*VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA;
†Victoria Johnson Research Laboratories, Virginia Commonwealth University, Richmond, VA;
‡Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;
Departments of §Medicinal Chemistry; and
¶Pharmacotherapy and Outcome Studies, Virginia Commonwealth University, Richmond, VA.
Reprints: Antonio Abbate, MD, PhD, VCU Pauley Heart Center, Box 980281, Virginia Commonwealth University, 1200 E. Broad St, Richmond, VA 23298 (e-mail: [email protected]).
C. Marchetti, J. Chojnacki, and S. Toldo equally contributed to the realization of this work.
S. Toldo, E. Mezzaroma, B. W. Van Tassell, and A. Abbate are supported by grants from the American Heart Association. S. W. Rose was supported by a VCU School Medicine Summer Research Award. S. Zhang is supported by an NIH R01 grant (AG041161).
Dr. Abbate, Dr. Van Tassell, Dr. Zhang and Virginia Commonwealth University hold a provisional patent on the compound. The authors report no conflicts of interest.
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jcvp.org).
Received September 23, 2013
Accepted November 20, 2013