Original ArticleCardioankle Vascular Index Evaluations Revealed That Cotreatment of ARB Antihypertension Medication With Traditional Chinese Medicine Improved Arterial FunctionalityXu, Yan MD*; Yan, Hua PhD*; Yao, Min J. PhD†; Ma, Jie PhD†; Jia, Jun M. PhD*; Ruan, Fen X. PhD*; Yao, Zeng C. PhD*; Huang, Hua M. MD*; Zheng, Jing PhD*; Chen, Ting PhD‡; Lv, Hua MD*; Endler, Alexander M. PhD§Author Information *Department of Cardiovascular Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China †Department of Cardiovascular Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China ‡Department of Endocrinological Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China §Department of Regenerative Medicine, School of Medicine, Tongji University, Shanghai, China. Reprints: Yan Xu, MD, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai 201203, China (e-mail: email@example.com). Supported by a grant from the Yan Shiyun inheritance studio of national brand Traditional Chinese Medicine doctor, State Administration of Traditional Chinese Medicine of China on the “eleven-five” program for special disease. The authors report no conflicts of interest. Y. Xu and H. Yan have contributed equally. Received July 16, 2012 Accepted October 25, 2012 Journal of Cardiovascular Pharmacology: May 2013 - Volume 61 - Issue 5 - p 355-360 doi: 10.1097/FJC.0b013e31827afddf Buy Metrics Abstract Abstract: Qian Yang He Ji (QYHJ) is a traditional Chinese medicine composed of Digitalis purpurea, Uncaria gambir, Fructus tribuli terrestris, and Ligustrum lucidum. Here, we explored whether combining an antihypertensive angiotensin II receptor blocker (ARB) therapy with QYHJ can improve the arterial functionality of hypertensive patients. One hundred and eight hypertensive patients were randomized into 2 groups; 1 group (n = 53) was treated with ARB and the other group (n = 55) was treated with ARB combined with QYHJ. Each of the 2 groups included 3 subgroups (pure hypertension, hypertension with diabetes, and hypertension with coronary heart disease) and was further divided into patients with and without complications. The cardioankle vascular index and intima-media thickness and pulse pressure were the outcome evaluation parameter. Combined QYHJ and ARB treatment reduced the values of cardioankle vascular index, systolic blood pressure, diastolic blood pressure, and pulse pressure to significantly lower levels than ARB treatment alone did in hypertension patients after 6 months of treatment. ARB improves hypertension, but a combined QYHJ treatment can additionally ameliorate the arterial functionality not only in solely hypertensive patients but also in hypertensive patients with diabetes and coronary heart disease complications. QYHJ coapplication might be a choice to further improve the arterial functionality during an ARB hypertension treatment. © 2013 Lippincott Williams & Wilkins, Inc.