Highlighted Meeting ArticleTRPV4 and the Regulation of Vascular ToneFilosa, Jessica A. MD, PhD*; Yao, Xiaoqiang BS, MS, PhD†; Rath, Geraldine PhD‡Author Information *Georgia Health Sciences University, Augusta, GA †Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China ‡Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium. Reprints: Geraldine Rath, PhD, Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, 1200 Brussels, Belgium (e-mail: email@example.com). This study was supported by grants from the National Heart, Lung and Blood Institute (R01 HL089067-02 to J.A.F.), Hong Kong Research Grant Council (TBRS T13-706/11 to X.Y.) and China National Science Foundation (31171100 to X.Y.), and Action Recherche Concertée 06/11339, Fond de Recherche Scientifique Medicale (3.4547.03; 3.4.555.08F to G.R.). The authors report no conflicts of interest. Received September 17, 2012 Accepted October 17, 2012 Journal of Cardiovascular Pharmacology: February 2013 - Volume 61 - Issue 2 - p 113-119 doi: 10.1097/FJC.0b013e318279ba42 Buy Metrics Abstract Abstract: Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (eg, shear stress, cell swelling, and heat) and chemical (eg, epoxyeicosatrienoic acids, endocannabinoids, and 4α-phorbol esters). In the brain, TRPV4 channels are primarily localized to astrocytic endfeet processes, which wrap around blood vessels. Thus, TRPV4 channels are strategically localized to sense hemodynamic changes and contribute to the regulation of vascular tone. TRPV4 channel activation leads to smooth muscle cell hyperpolarization and vasodilation. Here, we review recent findings on the cellular mechanisms underlying TRPV4-mediated vasodilation; TRPV4 channel interaction with other proteins including transient receptor potential channel 1, small conductance (KCa2.3), and large conductance (KCa1.1) calcium-activated potassium-selective channels; and the importance of caveolin-rich domains for these interactions to take place. © 2013 Lippincott Williams & Wilkins, Inc.