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Nebivolol Lowers Blood Pressure and Increases Weight Loss in Patients With Hypertension and Diabetes in Regard to Age

Ladage, Dennis MD*†; Reidenbach, Christian MD*†; Rieckeheer, Eva MD*; Graf, Christine MD, PhD*; Schwinger, Robert HG MD; Brixius, Klara PhD*

Journal of Cardiovascular Pharmacology: September 2010 - Volume 56 - Issue 3 - p 275-281
doi: 10.1097/FJC.0b013e3181eb4ff2
Original Article
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Background: In patients with diabetes mellitus type 2 and arterial hypertension, the control of systolic and diastolic blood pressure is essential to reduce the risk of adverse events. The present study investigates the effect of treatment with the third-generation β-blocker nebivolol, in female and male patients of different ages.

Methods: Five thousand thirty-one male and female patients with mild to moderate hypertension and type 2 diabetes were treated with a daily dose of 5-mg nebivolol for 12 weeks. Before and after therapy, each patient's blood pressure, heart rate, and body weight were measured and blood samples were obtained to study metabolic parameters.

Results: Nebivolol reduced systolic blood pressure, in both sexes, to a similar extent. In regard to age, the most significant reduction in blood pressure over the 12-week treatment period was observed in the group of patients below the age of 40. With advancing age, there was a decline in the reduction of systolic blood pressure induced by nebivolol. This effect was more evident among the decennial age groups in respect to diastolic blood pressure. In addition, we found weight reduction to be age dependent. Body weight was significantly more reduced in men compared with women.

Conclusions: Nebivolol is effective in treating patients with diabetes suffering from high blood pressure and metabolic syndrome. The significantly decreased effect on blood pressure found in elderly patients may be attributed to increased endothelial dysfunction with advancing age.

From the *Department of Molecular and Cellular Sport Medicine, Institute of Cardiology and Sport Medicine, German Sport University Cologne, Cologne, Germany; †Laboratory of Muscle Research and Molecular Cardiology, Department III for Internal Medicine, University of Cologne, Cologne, Germany; and ‡Clinic II of Internal Medicine and Cardiology, Weiden, Germany.

Received for publication February 23, 2010; accepted June 3, 2010.

We report financial support by a research grant from Berlin Chemie for this study.

This work contains data from the doctoral thesis of C. Reidenbach and E. Rieckeheer.

The authors declare no conflict of interest.

Reprints: Klara Brixius, PhD, Department of Molecular and Cellular Sport Medicine, Institute of Cardiology and Sport Medicine, German Sport University Cologne, Carl-Diem-Weg 6, 50933 Cologne, Germany (e-mail: brixius@dshs-koeln.de).

© 2010 Lippincott Williams & Wilkins, Inc.