Invited Review ArticleCalcium/Calmodulin-dependent Kinase II Regulation of Cardiac Ion ChannelsBers, Donald M PhD; Grandi, Eleonora PhDAuthor Information From the Department of Pharmacology, University of California, Davis, Davis, CA. Received for publication January 8, 2009; accepted February 23, 2009. Supported by NIH grants (R37-HL30077, R01-HL64274, P01-HL80101) and from the Fondation Leducq. The authors report no conflicts of interest. Reprints: Donald M. Bers, PhD, Department of Pharmacology, University of California, Davis, 451 Health Sciences Dr, GBSF Room 3513, Davis, CA 95616-8636 (e-mail: [email protected]). Journal of Cardiovascular Pharmacology: September 2009 - Volume 54 - Issue 3 - p 180-187 doi: 10.1097/FJC.0b013e3181a25078 Buy Metrics Abstract Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase expressed abundantly in the heart. CaMKII targets numerous proteins involved in excitation-contraction coupling and excitability, and its activation may simultaneously contribute to heart failure and cardiac arrhythmias. In this review, we summarize the modulatory effects of CaMKII on cardiac ion channel function and expression and illustrate potential implications in the onset of arrhythmias via a computer model. © 2009 Lippincott Williams & Wilkins, Inc.