Invited Review ArticleNeurohormonal Regulation of Cardiac Ion Channels in Chronic Heart FailureKurokawa, Junko PhD*; Abriel, Hugues MD, PhD†Author Information From the *Department of Bio-Informational Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan; and †Department of Clinical Research, University of Bern, Bern, Switzerland. Received for publication January 21, 2009; accepted June 9, 2009. Supported by a grant of the Swiss National Science Foundation to HA (310030_ 120707) and by grants from the Ministry of Education, Science, Culture, Sports and Technology of Japan (19689006) and Naito Foundation to J. Kurokawa. The authors report no conflicts of interest. Reprints: Hugues Abriel, MD, PhD, Department of Clinical Research, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland (e-mail: [email protected]). Journal of Cardiovascular Pharmacology: August 2009 - Volume 54 - Issue 2 - p 98-105 doi: 10.1097/FJC.0b013e3181b2b6d4 Buy Metrics Abstract Alteration of neurohormonal homeostasis is a hallmark of the pathophysiology of chronic heart failure (CHF). In particular, overactivation of the renin-angiotensin-aldosterone system and the sympathetic catecholaminergic system is consistently observed. Chronic overactivation of these hormonal pathways leads to a detrimental arrhythmogenic remodeling of cardiac tissue due to dysregulation of cardiac ion channels. Sudden cardiac death resulting from ventricular arrhythmias is a major cause of mortality in patients with CHF. All the drug classes known to reduce mortality in patients with CHF are neurohormonal blockers. The aim of this review was to provide an overview of how cardiac ion channels are regulated by hormones known to play a central role in the pathogenesis of CHF. © 2009 Lippincott Williams & Wilkins, Inc.