Invited Review ArticleMechanosensitive Channels in Striated Muscle and the Cardiovascular System: Not Quite a Stretch AnymoreStiber, Jonathan A MD; Seth, Malini PhD; Rosenberg, Paul B MDAuthor Information From the Department of Medicine, Duke University Medical Center, Durham, NC. Received for publication January 2, 2009; accepted March 30, 2009. Supported by a HHMI Physician-Scientist Early Career Award and NIH award (K08-HL077520) (JAS), NIH award (K08-HL-071841-04) (PBR), Mandel Foundation award (PBR), and a MDA research award (PBR). The authors report no conflicts of interest. Reprints: Paul B. Rosenberg, MD, 4321 Medical Park Drive, Suite 200, Durham, NC 27704 (e-mail: [email protected]). Journal of Cardiovascular Pharmacology: August 2009 - Volume 54 - Issue 2 - p 116-122 doi: 10.1097/FJC.0b013e3181aa233f Buy Metrics Abstract Stretch-activated or mechanosensitive channels transduce mechanical forces into ion fluxes across the cell membrane. These channels have been implicated in several aspects of cardiovascular physiology including regulation of blood pressure, vasoreactivity, and cardiac arrhythmias, as well as the adverse remodeling associated with cardiac hypertrophy and heart failure. This review discusses mechanosensitive channels in skeletal muscle and the cardiovascular system and their role in disease pathogenesis. We describe the regulation of gating of mechanosensitive channels including direct mechanisms and indirect activation by signaling pathways, as well as the influence on activation of these channels by the underlying cytoskeleton and scaffolding proteins. We then focus on the role of transient receptor potential channels, several of which have been implicated as mechanosensitive channels, in the pathogenesis of adverse cardiac remodeling and as potential therapeutic targets in the treatment of heart failure. © 2009 Lippincott Williams & Wilkins, Inc.