Invited Review ArticleAnkyrin-based Patterning of Membrane Microdomains: New Insights Into a Novel Class of Cardiovascular DiseasesNilsson, Kent R Jr MD*; Bennett, Vann MD, PhD†‡Author Information From the *Division of Cardiology, Department of Medicine; †Department of Cell Biology, Duke University Medical Center, Durham, NC; and ‡Howard Hughes Medical Institute, Durham, NC. Received for publication February 11, 2009; accepted June 3, 2009. K. Nilsson received support from National Institute of Health T32 5T32-HL007101-34 and a grant from the Medtronic Duke University Strategic Alliance (MEDUSA). V. Bennett was supported, in part, by a grant from the Muscular Dystrophy Association. The authors report no conflicts of interest. Reprints: Kent Nilsson, MD, Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27713 (e-mail: [email protected]). Journal of Cardiovascular Pharmacology: August 2009 - Volume 54 - Issue 2 - p 106-115 doi: 10.1097/FJC.0b013e3181b2b6ed Buy Metrics Abstract The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and force-transducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc. © 2009 Lippincott Williams & Wilkins, Inc.