We have synthesized two potential positron emission tomography (PET) radioligands for the endothelin (ET) receptor. [11C]-PD156707 was produced by O-methylation of PD169390 using [11C]iodomethane. Radiochemical conversions of the order of 74 ± 3.2% (n = 8) were obtained. The radiochemical purity of the isolated [11C]-PD156707 was 99% and the specific activity was 538 mCi/μmol. [18F]-BQ3020 was produced from [18F]fluoride in a total radiochemical yield of 2.7 ± 0.4% (n = 10) in 238 ± 5 min. The radiochemical purity was 95% and specific activities of the order of 670-930 mCi/μmol were obtained.
Clinical Pharmacology Unit and *Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, U.K.
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