Knockout (KO) models have provided important insights into the function of many receptors and signalling molecules. However, analysis of endothelin (ET) receptor knockouts has been complicated by the development of lethal phenotypes. In this paper, we present our strategy for examining endothelin-B- (ETB) receptor function in the context of other strategies for rescuing the lethal phenotype of ETB knockout mice.
*Wellcome Trust Clinical Research Fellow, †Christison Professor of Therapeutics and Pharmacology, ‡Lecturer in Molecular Cardiology, University of Edinburgh, U.K.
Address correspondence and reprint requests to Dr Alan Bagnall, Department of Medical Science, Western General Hospital, Crewe Road, Edinburgh, Scotland.
© 2000 Lippincott Williams & Wilkins, Inc.