Tomita Kimio; Nonoguchi, Hiroshi; Terada, Yoshio; Marumo, FumiakiJournal of Cardiovascular Pharmacology: October 1992 Articles: PDF Only Free Abstract Summary: Short-term effects of alacepril, an angiotensin-converting enzyme inhibitor (ACEI), on renal function and hemodynamics were investigated in 10 hypertensive subjects (aged 55.7 ± 9.5 years, mean ± SD). Renal plasma flow (RPF) and glomerular filtration rate (GFR) were examined before and after 12-week administration of alacepril, by [131I]hippuran and [99mTc]DTPA, respectively. Alacepril (50 mg/day) caused a significant decrease in both systolic and diastolic blood pressure (SBP and DBP, from 161 ± 8 to 140 ± 10 mm Hg and from 100 ± 3 to 90 ± 5 mm Hg, respectively). Alacepril increased GFR (from 63.4 ± 22.2 to 69.1 ± 22.1 ml/min/1.73 m2, p < 0.05) without changing RPF (from 438 ± 194 to 432 ± 148 ml/ min/1.73 m2, p > 0.05). Serum creatinine and electrolytes were not changed by alacepril administration. These data show that short-term alacepril administration improves renal function, probably owing to relaxation of renal vasoconstriction © Lippincott-Raven Publishers.