Original Article: PDF OnlyChopra M; Beswick, H; Clapperton, M; Dargie, H J; Smith, W E; McMurray, JJournal of Cardiovascular Pharmacology: March 1992 - p 330-340 Free Abstract Summary: With an assay that generates free radicals (FR) through photooxidation of dianisidine sensitized by riboflavin, 4 × 10−5M captopril, epicaptopril (SQ 14,534, captopril's stereoisomer), zofenopril, and fentiapril [all sulfhydryl (-SH)-containing angiotensin-converting enzyme (ACE) inhibitors] were shown effective scavengers of nonsuperoxide free radicals whereas non-SH ACE inhibitors were not. Captopril was a more effective FR scavenger at pH 5.0 than at pH 7.5. Captopril (2 × 10−5M) also scavenged the other toxic oxygen species hydrogen peroxide and singlet oxygen and inhibited microsomal lipid peroxidation. Finally, captopril reduced the amount of superoxide anion-radical detected after neutrophils in whole blood were activated with zymosan, probably by inhibiting leukocyte superoxide production. © Lippincott-Raven Publishers.