Article: PDF OnlyThe Place of Calcium Antagonists in the Prophylactic Treatment of MigraineLudin, Hans-PeterAuthor Information Neurological Clinic, Kantonsspital, St. Gallen, Switzerland Journal of Cardiovascular Pharmacology: Volume 18 - Issue - p S17-S19 Free Abstract Migraine patients suffering from frequent and severe attacks may need prophylactic treatment. Propranolol, a β-receptor blocker, and flunarizine, a calcium antagonist, are considered to be the most effective compounds for the prophylaxis of migraine. In a number of controlled studies, flunarizine has been shown to reduce the number of migraine attacks significantly. In migraine studies, sedation and weight gain are the most frequent side effects of flunarizine. Copyright © 1991 Wolters Kluwer Health, Inc. All rights reserved.