Article: PDF OnlyCalcium Channels in the Brain as Targets for the Calcium-Channel Modulators Used in the Treatment of Neurological DisordersPeters, Th.; Wilffert, B.; Vanhoutte, P. M.; van Zwieten, P. A.Author Information Department of Experimental Medicine, Janssen Research Foundation, Neuss, F.R.G.; * Center for Experimental Therapeutics, Baylor College of Medicine, Houston, Texas, U.S.A.; and †Departments of Pharmacotherapy and Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands Journal of Cardiovascular Pharmacology: Volume 18 - Issue - p S1-S5 Free Abstract Recent investigations of calcium channels in brain cells by voltage-clamp techniques have revealed that, in spite of electrophysiological similarities, the pharmacological properties of these channels differ considerably from channels in peripheral tissues, e.g., heart and smooth muscle. Therefore, instead of extrapolation from results obtained on cardiac or smooth muscle cells, a reclassification of calcium-channel modulators applied in disorders of the brain appears necessary. The present article reviews some pertinent observations from groups involved in neuronal calcium-channel characterization and draws the attention to major pharmacological differences on neurons in comparison to those in the heart and in smooth muscle. For certain therapeutic applications in neurology particularly, the low-voltage activated types of calcium channels deserve considerable attention. Copyright © 1991 Wolters Kluwer Health, Inc. All rights reserved.