Article: PDF OnlyRuilope Luis M.Journal of Cardiovascular Pharmacology: 1991 - p S10-S13 Free Abstract Summary Calcium-entry Mockers exert several characteristic effects on the kidney that potentiate their antihypertensive effect. Long-term therapy with nitrendipine, a dihydropyridine derivative, lowers blood pressure while maintaining renal hemodynamics within limits similar to pretreatment values in esential hypertension with normal renal function. This is accompanied by a persistent natriuretic effect that probably facilitates its antihypertensive action and is not followed by changes of the renin–angiotensin–aldosterone system. Preliminary data also seem to indicate that nitrendipine could he safely used in patients with arterial hypertension and chronic renal failure. Copyright © 1991 Wolters Kluwer Health, Inc. All rights reserved.