Article: PDF OnlyDurrington P. N.; Winocour, P. H.; Bhatnagar, D.Journal of Cardiovascular Pharmacology: 1990 - p S30-S34 Free Abstract Summary The effects of a sustained-release preparation of bezafibrate (Bezalip Mono) 400 mg once daily and placebo administered for 3 months were compared in 36 patients with stable type 1 diabetes and hypercholesterolemia and/or hypertriglyceridemia. There was a significant decrease in fasting glucose levels with bezafibrate, but not in glycosylated hemoglobin. The serum cholesterol concentration decreased on bezafibrate [from 7.1 ± 0.2 (mean ± SEM) to 6.3 ± 0.3 mmol/L; p < 0.05] predominantly due to a reduction in low-density lipoprotein (LDL) cholesterol [from 4.8 ± 0.3 to 4.2 ± 0.3 mmol/L; p < 0.05. There was also a decrease in fasting serum triglycerides with bezafibrate [1.82 to 1.26 mmol/L (geometric mean)] and in very-low-density lipoprotein (VLDL) cholesterol. Plasma fibrinogen decreased significantly with bezafibrate (from 4.1 ± 0.2 to 2.9 ± 0.2 g/L; p < 0.001). Serum apolipoproteins B and A showed no statistically significant changes. Overall, there was no change in high-density lipoprotein (HDL). However, in patients who were initially hypertriglyceridemic, there was a significant increase in the cholesterol content of total HDL and the HDL2 subfraction (both p < 0.05). It is concluded that in insulin-dependent diabetic patients with hyperlipidemia, bezafibrate is effective in lowering both serum VLDL and LDL. In addition, it has a potentially important action in decreasing plasma fibrinogen levels. Copyright © 1990 Wolters Kluwer Health, Inc. All rights reserved.