Article: PDF OnlyDoyle A. E.; Donnan, G. A.Journal of Cardiovascular Pharmacology: 1990 - p S34-S37 Free Abstract Summary Stroke is a major clinical problem in hypertension. Cerebral hemorrhage has become considerably less frequent since treatment of hypertension has become more widely used. Antihypertensive treatment has also reduced the incidence of lacunar stroke, which is a result of hypertensive vascular disease of small arteries. Cortical cerebral infarction due to embolus from extracranial arterial atheromatous plaques is now the most common clinical cause of stroke. Drug treatment for hypertension has probably not reduced the incidence of this type of stroke. Cigarette smoking is also associated with an increased incidence of stroke: the incidence is related to the amount smoked, and former smokers continue to he at increased risk for up to 10 years. Copyright © 1990 Wolters Kluwer Health, Inc. All rights reserved.