Relationship of Substance P to Catecholamines, Stress, and Hypertension: PDF OnlyOehme P.; Hecht, K.; Faulhaber, H.-D.; Nieber, K.; Roske, I.; Rathsack, R.Journal of Cardiovascular Pharmacology: 1987 - p S109-S111 Free Abstract Summary: This paper presents results on the function of the adrenal medulla, especially the influence of substance P (SP) on the cholinergic-adrenergic interaction. Interconnections between the function of SP and its role in the development and maintenance of hypertension as well as its role in stress and adaption are investigated. Substance P acts only in situations with an increased nervous activity, for example, after stress-induced activation of the pituitary-adrenal and sympathetic-adrenal axis. Substance P normalizes stress-induced disorders by maintaining homeostasis in the catecholamine system. The basis of the antistress effect is the modulation of both biosynthesis and release of catecholamines in the adrenals. The homeostasis effect of SP, as well as the antistress effect do not require the complete sequence of the molecule. The N-terminal SP fragment is fully active and has no side effects. Address correspondence and reprint requests to Prof. Dr. P. Oehme at Institute of Drug Research, Academy of Sciences of the G.D.R., Alfred-Kowalke-Str. 4, Berlin 1136, German Democratic Republic. © Lippincott-Raven Publishers.