Dissociation Between Heart Rate and Sympathetic Nerve Responses to Baroreceptor Activation in Spontaneously Hypertensive Rats: PDF OnlyUnger Thomas; Demmert, Gudrun; Rohmeiss, Peter; Veelken, Roland; Luft, Friedrich C.Journal of Cardiovascular Pharmacology: 1987 - p S221-S224 Free Abstract Summary: We tested the baroreflex in conscious, strokeprone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto controls (WKY) with incremental bolus injections of nitroprusside and methoxamine. The change in heart rate (HR) per change in mean blood pressure (MAP) was greater in WKY than in SHRSP. In contrast, the change in splanchnic nerve activity (SpNA) per change in MAP was greater in SHRSP than in WKY. The sympathetic outflow in SHRSP seems more reactive to blood pressure changes than in WKY. The discordance in HR and SpNA changes suggests that the integration of autonomic function in SHRSP is impaired. Address correspondence and reprint requests to Dr. T. Unger at Dept. of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 6900 Heidelberg, Federal Republic of Germany. © Lippincott-Raven Publishers.