Clinical Pharmacology of Vasodilator Peptides: PDF OnlyBrown M. J.; Morice, A. H.Journal of Cardiovascular Pharmacology: 1987 - p S82-S87 Free Abstract Summary: Several neuropeptides cause mild flushing when infused intravenously in humans. However, only calcitonin gene-related peptide (CGRP), vasointestinal peptide, and substance P (SP) cause reproducible falls in blood pressure when infused into normal subjects. Of these, CGRP is of the most interest because it is the most potent and because it is present in vascular nerve endings. This paper summarises the evidence to date suggesting that CGRP release from vascular nerve endings may be of physiological importance in the regulation of blood pressure. Address correspondence and reprint requests to Dr. M.J. Brown at Clinical Pharmacology Unit, F&G Block, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2QQ, England. © Lippincott-Raven Publishers.