Brain Glutathione and Blood Pressure Control: PDF OnlyMurakami Eiki; Iwata, Takeru; Hiwada, Kunio; Kokubu, TatsuoJournal of Cardiovascular Pharmacology: 1987 - p S112-S115 Free Abstract Summary: The role of glutathione in the central nervous system in regulating blood pressure (BP) and sympathetic nerve activity (SNA) was investigated in rats. Intracerebroventricular (ICV) injection of glutathione disulfide (GSSG: 1.7-33 nmol) resulted in a dose-dependent increase in BP [δ mean BP: 17 ± 1 mm Hg (n = 7) for 33-nmol dose] together with a marked increase in SNA [163 ± 13 to 672 ± 70 spikes/10 s (n = 7), p < 0.001]. Intracerebroventricular administration of its reduced form (GSH, 33 nmol) produced a vasodepressor response (δ mean BP: −9 ± 2 mm Hg) accompanied by a corresponding decrease in SNA [192 ± 15 to 54 ± 22 spikes/10 s (n = 6), p < 0.01]. These responses were not due to a leakage into the systemic circulation, since intravenous injection of GSSG or GSH (33 nmol) did not show any cardiovascular effects. Electrical stimulation of the posterior hypothalamus induced hypertension with a significant decrease of GSSG in the brain stem. The results indicate that GSSG has a stimulatory control over the sympathetic nervous system while GSH has an inhibitory effect on SNA. Glutathione disulfide and GSH may act within the central nervous system to modulate the tone of the sympathetic nervous system. Address correspondence and reprint requests to Prof. T. Kokubu at the 2nd Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun, Ehime 791-02, Japan. © Lippincott-Raven Publishers.