ARTICLE: PDF OnlyWebb David J.; Manhem, Per J. O.; Ball, Stephen G.; Inglis, Gordon; Leckie, Brenda J.; Lever, Anthony F.; Morton, James J.; S. Robertson, J. Ian; Murray, Gordon D.; Menard, Joel; Hallett, Allan; Jones, D. Michael; Szelke, MichaelJournal of Cardiovascular Pharmacology: 1987 - p 69-74 Free Abstract Summary The inhibitor of human renin, H 142, was studied in nine male volunteers. On three occasions, in random order, volunteers were infused with 5% dextrose, or with H142 at 1.0 or 2.5 mg/kg/h, for 30 min while supine and thereafter with dextrose for 1.5 h. There was a marked reduction in plasma active renin concentration as assayed by an enzyme-kinetic method, with parallel falls in the circulating concentrations of angiotensins (ANG) I and II, all of which rebounded transiently to values above basal after H142 infusion was stopped. In contrast, total renin concentration as measured by radioimmunoassay rose while ANG I and II fell, subsiding after H 142 was discontinued. There was a slight but significant increase in plasma noradrenaline as renin became inhibited: plasma adrenaline was unchanged. H 142 produced a slight fall in systolic blood pressure (SBP) and a clearer, highly significant, dose-related fall in diastolic blood pressure (DBP). There was modest but significant in-crease in the heart rate. These studies confirm H 142 as an effective inhibitor of human renin in vivo. Copyright © 1987 Wolters Kluwer Health, Inc. All rights reserved.