Article: PDF OnlyCorsing C.; Varchmin, G.; Stoepel, K.Journal of Cardiovascular Pharmacology: 1987 - p S136-S139 Free Abstract Summary Efficacy and tolerance of nitrendipine (20 mg) given once daily in long-term therapy (> 300 days) were evaluated in a subgroup of 214 patients of a data pool. Three age groups were examined: < 50 years, 51–60 years, and > 60 years. All groups showed a sufficient decrease of blood pressure: mild hypertensives, from 167/99 to 146/83 mm Hg; moderate hypertensives, from 177/108 to 152/84 mm Hg. Six patients did not respond to therapy. The heart rate increased only temporarily (<2/min). No differences in heart rate could be found in the three age groups, except that heart rate in the middle-aged group did not increase. Adverse effects were noted in 61 patients (28.5%). A correlation between sex and side effects was not seen. The middle-aged group showed the lowest incidence of side effects (14.8%). Headache and dizziness appeared mainly in older patients; flush, palpitations, and nervousness predominantly occurred in younger patients. Changes in laboratory values did not indicate arty abnormal effects on these variables. Thus, nitrendipine therapy with 20 mg once daily is an effective and well-tolerated antihypertensive regimen. © Lippincott-Raven Publishers.