Article: PDF OnlyNorepinephrine-induced Intracellular Ca2+ Release from Vascular Smooth MuscleLeijten, P.; Saida, K.; van Breemen, C. Author Information Department of Pharmacology, University of Miami School of Medicine, Miami, Florida Journal of Cardiovascular Pharmacology: Volume 7 - Issue - p S38-S42 Free Abstract In rabbit aorta and superior mesenteric artery, application of NE causes release of Ca2+ from an intracellular Ca2+ store, probably SR. The amount of released Ca2+ is sufficient to activate the myofilaments submaximally. It is suggested that NE mediates Ca2+ release by a rapid increase in the free Ca2+ concentration near the SR (Ca2+ -induced Ca2+ release). The uptake of Ca2+ into the store and the Ca2+ -induced Ca2+ release is modulated by c-AMP. © Lippincott-Raven Publishers.
