Article: PDF OnlyEffect of β-Blocking Drugs on Peripheral Blood Flow in Intermittent ClaudicationSmith, R. S.; Warren, D. J. Author Information Hypertension Laboratory, Department of Renal Medicine, University of Southampton, St. Mary's Hospital, Portsmouth, England Journal of Cardiovascular Pharmacology: January 1982 - Volume 4 - Issue 1 - p 2-4 Free Abstract Summary To determine the possible effects of β-adrenergic blocking drugs on blood flow in arteriosclerotic peripheral vascular disease, we have measured muscle blood flow in eight patients with intermittent claudication who were taking β-blocking drugs for mild uncomplicated hypertension. Patients completed a double-blind trial of 2 weeks' treatment with propranolol 80 mg three times daily, pindolol 5 mg three times daily, atenolol 100 mg daily, or placebo. Mean exercise muscle blood flow fell by approximately 30% after each active drug when compared to placebo. β-Blocking drugs may be contraindicated in the presence of peripheral vascular disease. Cardioselectivity and partial agonist activity appear to confer no advantages in such patients. © Lippincott-Raven Publishers.
