Review ArticleAn Exploration of the Relationship Between Atrial Fibrillation and ObesityUpadhyay, Kiran MD; Frishman, William H. MD Author Information From the Department of Medicine NYU Long Island and Departments of Medicine and Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY. The authors declare no conflicts of interest. Correspondence: William H. Frishman, MD, Department of Medicine, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595. E-mail: [email protected]. Cardiology in Review ():10.1097/CRD.0000000000000490, January 23, 2023. | DOI: 10.1097/CRD.0000000000000490 Buy PAP Metrics Abstract In the past 40 years, the prevalence of atrial fibrillation and obesity have skyrocketed. It has long been established that obesity can lead to adverse cardiovascular outcomes due to its myriad of effects on cardiovascular architecture, cardiovascular hemodynamics, and electrical conduction interference. The goal of this article is to explore the pathogenesis of atrial fibrillation in obese patients and examine the role of atrial enlargement, increased adipose deposits surrounding the pericardium, interstitial fibrosis, and inflammation in the development and worsening of atrial fibrillation in obese patients. Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.