Invited Review Article: PDF OnlyRole of Micro RNA in Heart TransplantNog, Rajat MD1; Gupta, Chhaya Aggarwal MD2; Panza, Julio A MD2Author Information 1Division of Transpla Infectious Diseases, Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY, USA 2Department of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY, USA The authors of this manuscript have no conflicts of interest to disclose Address for correspondence: Chhaya Aggarwal Gupta, MD Department of Cardiology Westchester Medical Center Macy Pavilion, Room 112 100 Woods Road, Valhalla, NY 10595 Telephone number: 914-493-7632 Fax number: 914-493-1203 E-mail: [email protected] Cardiology in Review: April 12, 2021 - Volume - Issue - doi: 10.1097/CRD.0000000000000393 Buy PAP Metrics Abstract The need for non-invasive biomarkers for diagnostic, prognostic, and therapeutic purposes is increasingly being recognized in the field of heart transplantation. MicroRNAs are a class of novel biomarkers that control gene expression and influence cellular functions, including differentiation, proliferation and functional regulation of the immune system. They can be detected in the serum, plasma, and urine, and may serve as early noninvasive biomarkers for various disease processes. Despite significant advances in heart transplantation, challenges remain in the short and long term with early graft injury and dysfunction, both cellular and antibody mediated rejection, infections of varying types and severity, and cardiac allograft vasculopathy, which require an interventional approach for diagnosis and management. In this article, we review the current knowledge on the role of microRNAs in heart transplantation and its related complications, and discuss their potential impact in future strategies to manage heart transplantation. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.