Review ArticlesLoeffler’s Endocarditis and Hypereosinophilic SyndromeSalih, Mohammed MD*; Ibrahim, Ramzi MS3*; Tirunagiri, Deepthi MD*; Al-ani, Hadeel MD*; Ananthasubramaniam, Karthik MD, FACC†Author Information From the *Department of Internal Medicine and Cardiology, St Joseph Mercy Oakland Hospital, Pontiac, MI †The Heart and Vascular Institute, Henry Ford West Bloomfield Hospital, West Bloomfield, MI. Disclosure: The author has no conflicts of interest to report. Correspondence: Karthik Ananthasubramaniam, MD, FACC, Heart and Vascular Institute, Henry Ford West Bloomfield Hospital, 6777 West Maple, West Bloomfield, MI 48322. E-mail: [email protected]. Cardiology in Review: May/June 2021 - Volume 29 - Issue 3 - p 150-155 doi: 10.1097/CRD.0000000000000324 Buy Metrics Abstract Loeffler’s endocarditis and hypereosinophilic syndromes are a unique group of infiltrative disorders characterized by hypereosinophilia, inflammatory thrombotic, and ultimately, fibrotic involvement of the heart leading to multiple complications including valve involvement, thromboembolic phenomena, heart failure. Clinical recognition, comprehensive laboratory and multimodality imaging diagnostic workup, and early initiation of treatment have been shown to slow down the progression and promote remission. This review addresses a detailed analysis of Loeffler’s endocarditis and hypereosinophilic syndromes. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.