Westchester Cardiovascular Symposium: October 3-5, 2019 Guest Editors: Julio Panza MD, Steven Lansman MD, PhDNoninvasive Radioablation of Ventricular TachycardiaAthar, Ammar M. MD*; Nabors, Christopher C. MD, PhD*; Dhaduk, Kartik MD*; Yandrapalli, Srikanth MD†; Jain, Anant MD*; Moorthy, Chitti R. MD‡; Halperin, Edward C. MD, MA§; Iwai, Sei MD, FACC, FHRS†; Frishman, William H. MD*; Jacobson, Jason MD, FACC, FHRS†Author Information From the *Department of Medicine †Division of Cardiology ‡Department of Radiation Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY §Chancellor and CEO, New York Medical College (NYMC) and Provost of Biomedical Affairs, Touro College and University System, NY Disclosures: The authors have no conflicts of interest to report. Correspondence: Ammar M. Athar, MD, 1763 2nd Avenue Apt 28Q New York, NY 10128. E-mail: email@example.com Cardiology in Review: November/December 2020 - Volume 28 - Issue 6 - p 283-290 doi: 10.1097/CRD.0000000000000321 Buy Metrics Abstract Ventricular tachycardia (VT) occurs most commonly in the presence of structural heart disease or myocardial scarring from prior infarction. It is associated with increased mortality, especially when it results in cardiac arrest outside of a hospital. When not due to reversible causes (such as acute ischemia/infarction), placement of an implantable cardioverter-defibrillator for prevention of future sudden death is indicated. The current standard of care for recurrent VT is medical management with antiarrhythmic agents followed by invasive catheter ablation for VT that persists despite appropriate medical therapy. Stereotactic arrhythmia radioablation (STAR) is a novel, noninvasive method of treating VT that has been shown to reduce VT burden for patients who are refractory to medical therapy and/or catheter ablation, or who are unable to tolerate catheter ablation. STAR is the term applied to the use of stereotactic body radiation therapy for the treatment of arrhythmogenic cardiac tissue and requires collaboration between an electrophysiologist and a radiation oncologist. The process involves identification of VT substrate through a combination of electroanatomic mapping and diagnostic imaging (computed tomography, magnetic resonance imaging, positron emission tomography) followed by carefully guided radiation therapy. In this article, we review currently available literature describing the utilization, efficacy, safety profile, and potential future applications of STAR for the management of VT. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.