Review ArticlesStem Cell Therapy for Acute Myocardial Infarctions A Systematic ReviewRudman, Joseph MD*; Frishman, William H. MD†Author Information From the *Department of Internal Medicine, Zucker School of Medicine-Northwell Staten Island University †Department of Medicine, New York Medical College, Westchester Medical Center, Valhalla, NY. Disclosure: The authors have no conflicts of interest to report. Correspondence: William H. Frishman, MD, Department of Medicine, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY 10595. E-mail: firstname.lastname@example.org. Cardiology in Review: May/June 2020 - Volume 28 - Issue 3 - p 140-147 doi: 10.1097/CRD.0000000000000291 Buy Metrics Abstract Each year 790,000 people in the United States suffer from a myocardial infarction. This results in the permanent loss of cardiomyocytes and an irreversible loss of cardiac function. Current therapies lower mortality rates, but do not address the core pathology, which opens a pathway to step-wise heart failure. Utilizing stem cells to regenerate the dead tissue is a potential method to reverse these devastating effects. Several clinical trials have already demonstrated the safety of stem cell therapy. In this review, we highlight clinical trials, which have utilized various stem cell lineages, and discuss areas for future research. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.