Review ArticlesCardiovascular Sequelae of Sickle Cell DiseaseAujla, Amandeep MD*; Dutta, Dibyendu PhD†; Amar, Salomon DDS, PhD‡; Frishman, William MD*,†; Lim, Seah H. MD, PhD*,†Author Information From the *Department of Medicine, Westchester Medical Center †Department of Medicine, New York Medical College ‡Department of Immunology and Microbiology, New York Medical College, Valhalla, NY. Disclosure: The authors have no conflicts of interest to report. A.A. and D.D. are equal first authors. Correspondence: Seah H Lim, MD, PhD, Westchester Medical Center Cancer Institute, 19 Bradhurst Avenue, Suite 2575S, Hawthorne, NY 10532. E-mail: email@example.com. Cardiology in Review: January/February 2020 - Volume 28 - Issue 1 - p 10-13 doi: 10.1097/CRD.0000000000000264 Buy Metrics Abstract Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies worldwide. It is a multisystem disease that causes considerable patient morbidity. Despite advances in medical treatment, cardiopulmonary complications remain the most common cause of death in individuals with SCD. A growing body of evidence has shown that SCD results in a spectrum of cardiovascular complications through a variety of mechanisms, including chronic hemolysis, local tissue hypoxia, increased oxidative stress, and autonomic instability. Herein, we will examine the pathophysiology of sickle cell vasculopathy and discuss the spectrum of cardiovascular sequelae of the disease, while highlighting the impact of SCD on the cardiovascular health of the patients. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.