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Very Late Stent Thrombosis in Drug-Eluting Stents New Observations and Clinical Implications

Wang, Xiang PhD*; Chen, Xinxin PhD*; Sun, Wanqing PhD; Tian, Tao MD*; Zhou, Shanshan PhD*; Zhang, Zhiguo PhD*; Gao, Ming PhD*; Qiao, Bokang PhD; Zheng, Yang PhD*

doi: 10.1097/CRD.0000000000000283
Review Articles

Despite the reduction in stent failure with newer-generation drug-eluting stents, very late stent thrombosis (VLST) remains an unpredictable and potentially catastrophic complication of coronary revascularization procedures and is associated with high morbidity and mortality. Here, we present an updated overview of the latest advances in understanding the causes of VLST. Clinical studies that revealed potential risk factors and pathophysiologic studies on the mechanisms of VLST are discussed. Importantly, novel insights from recent advances in intravascular imaging are included. To date, there is no clinical guideline for VLST treatment. We propose an evidence-based recommendation that an intravascular-imaging-informed percutaneous coronary intervention strategy combined with optimized antiplatelet therapy is the foundation for successful VLST clinical management. Moreover, the future of VLST prevention, such as improved patient risk stratification and advances in addressing late stent failure, are also discussed.

From the *Department of Cardiovascular Disease Center, First Hospital of Jilin University, Jilin University, Jilin, China

State Key Laboratory of Cardiovascular Disease, Cardiovascular Institute, Fuwai Hospital and National Centre for Cardiovascular Diseases, Chinese academy of Medical Sciences & Peking Union Medical College, Beijing, China

Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Disclosure: The authors declare no conflict of interest.

Correspondence: Yang Zheng, PhD, Department of Cardiovascular Disease Center, First Hospital of Jilin University, Jilin University, No.71 Xinmin Ave, Changchun, Jilin, 130021, China. E-mail:

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