Review ArticlesInfectious Endocarditis After Transcatheter Aortic Valve Replacement Epidemiology and OutcomesKuttamperoor, Francis MD*; Yandrapalli, Srikanth MD†; Siddhamsetti, Sisir MD‡; Frishman, William H. MD§; Tang, Gilbert H. L. MD, MSc, MBA¶Author Information From the *Department of Medicine, Greenwich Hospital-Yale University, Greenwich, CT †Department of Medicine, Division of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY ‡Department of Medicine, Cook County Hospital, Chicago, IL §Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY ¶Division of Cardiothoracic Surgery, Mount Sinai Medical Center, NY. Disclosure: The authors have no conflicts of interest to report. Correspondence: Srikanth Yandrapalli, MD, Division of Cardiology, Westchester Medical Center, 100 Woods Road, Macy Pavilion, Valhalla, NY 10595. E-mail: [email protected]. Cardiology in Review: September/October 2019 - Volume 27 - Issue 5 - p 236-241 doi: 10.1097/CRD.0000000000000244 Buy Metrics Abstract With the expansion of the indications of transcatheter aortic valve replacement (TAVR), it is being increasingly performed in older patients with aortic stenosis to improve their quality of life. However, TAVR is not without serious complications. Despite being infrequent, prosthetic valve endocarditis after TAVR is a deadly complication associated with high rates of mortality related to a delayed diagnosis from variable clinical presentations and nonconfirmatory imaging findings. Furthermore, lower intervention rates in these patients, due to their high surgical risk, increases overall mortality. Clinicians should be aware of the differences in presentation and postprocedural anatomical considerations that delay the diagnosis of infectious endocarditis post TAVR. Studies evaluating the role of the procedural setting, implant and access type, and periprocedural antibiotic prophylaxis on the development of prosthetic valve endocarditis, and consensus guidelines that address the appropriate diagnosis and management of prosthetic valve endocarditis after TAVR, are needed. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.