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Parathyroid Hormone and Cardiac Electrophysiology

A Review

Palmeri, Nicholas Osborn, MD*; Walker, Marcella Donovan, MD

doi: 10.1097/CRD.0000000000000250
Review Articles

Calcium has long been known to be essential to cardiac electrical activity. Parathyroid hormone (PTH) is the main regulator of serum calcium and is central to calcium homeostasis. Although there are significant data linking parathyroid disease states with changes in cardiac electrophysiology, most data have focused on how PTH modulates serum calcium to produce these effects. Close scrutiny of early literature demonstrates that the relationship between PTH and electrocardiographic changes is not straightforward, and numerous studies have linked PTH to arrhythmia. Basic science research has demonstrated that there is a basis for a direct role of PTH on cardiac electrophysiology outside of its effect on serum calcium. Later studies in secondary hyperparathyroidism indicate that PTH disturbances could have important implications for broad categories of patients with cardiovascular disease. The current review summarizes the existing literature on PTH and electrophysiology based on clinical and basic science studies of various parathyroid states, providing directions for future study.

From the *Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA

Division of Endocrinology, Columbia University Medical Center, New York, NY.

Disclosure: The authors have no conflicts of interest to report.

Correspondence: Nicholas Osborn Palmeri, MD, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215. E-mail:

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