Review ArticlesBrain-Heart Interactions in Traumatic Brain InjuryEl-Menyar, Ayman MD*†; Goyal, Abhishek MD‡; Latifi, Rifat MD§; Al-Thani, Hassan MD¶; Frishman, William MD‡ Author Information From the *Department of Surgery, Clinical Research, Westchester Medical Center, Valhalla, NY; †Clinical Medicine, Weill Cornell Medical College, Doha, Qatar; ‡Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY; §Department of Surgery, New York Medical College/Westchester Medical Center, Valhalla, NY; and ¶Department of Surgery, Trauma & Vascular Surgery, Hamad General Hospital, Qatar. Disclosure: The authors declare no conflict of interest. Correspondence: Ayman El-Menyar, MD, Department of Surgery, Clinical Research, Westchester Medical Center, Valhalla, NY. E-mail: [email protected]. Cardiology in Review: November/December 2017 - Volume 25 - Issue 6 - p 279-288 doi: 10.1097/CRD.0000000000000167 Buy Metrics Abstract The cardiovascular manifestations associated with nontraumatic head disorders are commonly known. Similar manifestations have been reported in patients with traumatic brain injury (TBI); however, the underlying mechanisms and impact on the patient’s clinical outcomes are not well explored. The neurocardiac axis theory and neurogenic stunned myocardium phenomenon could partly explain the brain-heart link and interactions and can thus pave the way to a better understanding and management of TBI. Several observational retrospective studies have shown a promising role for beta-adrenergic blockers in patients with TBI in reducing the overall TBI-related mortality. However, several questions remain to be answered in clinical randomized-controlled trials, including population selection, beta blocker type, dosage, timing, and duration of therapy, while maintaining the optimal mean arterial pressure and cerebral perfusion pressure in patients with TBI. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.