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The First Potassium Binder Approved in Over 50 Years

Vu, Betty N. PharmD; De Castro, Alyssa Mae PharmD; Shottland, David MD; Frishman, William H. MD; Cheng-Lai, Angela PharmD, BCPS

doi: 10.1097/CRD.0000000000000123
New Therapy Update

For over 50 years, there have been limited options for the management of hyperkalemia, especially among patients with chronic kidney disease (CKD), diabetic nephropathy, hypertension, and heart failure, who were receiving concomitant renin–angiotensin–aldosterone system (RAAS) inhibitor therapy. Hyperkalemia is a potential, life-threatening electrolyte abnormality that frequently challenges clinicians from maximizing the mortality benefit and organ-protective properties of RAAS inhibitors especially in CKD and heart failure populations. Patiromer is a novel nonabsorbed, cation-exchange polymer that binds and exchanges potassium for calcium, predominantly in the gastrointestinal tract. It has demonstrated potassium-lowering effects in normo- or hyperkalemic patients on concomitant RAAS inhibitors with heart failure, diabetic nephropathy, and CKD, in the PEARL-HF, AMETHYST-DN, and OPAL-HK studies, respectively. Across all studies, it appears to be generally effective and well tolerated, with adverse events predominantly gastrointestinal in nature. Additional investigational studies are needed to explore its use for an extended duration of treatment and in larger patient populations, as well as exploring drug–drug interactions. Overall, patiromer demonstrates a promising role in the chronic management of hyperkalemia that will allow optimization of RAAS inhibitor therapy, thus delaying progression of CKD and improving the mortality benefit in heart failure patients.

From the *Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy/RUSH University Medical Center, Downers Grove, IL; Department of Pharmacy, Montefiore Medical Center, Bronx, NY; Department of Medicine, Boston University Medical Center, Boston, MA; and §Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY.

Disclosure: The authors have no conflicts of interest to report.

Correspondence: Betty N. Vu, PharmD, Department of Pharmacy Practice, Midwestern University Chicago College of Pharmacy, 555 31st Street, Downers Grove, IL 60515. E-mail:

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