Other Review ArticlesInflammation in Coronary Artery DiseaseChristodoulidis, Georgios MD*; Vittorio, Timothy J. MS, MD†; Fudim, Marat MD‡; Lerakis, Stamatios MD§; Kosmas, Constantine E. MD, PhD¶Author Information From the *Department of Internal Medicine, Winthrop University Hospital, Mineola, NY; †St. Francis Hospital, The Heart Center, Division of Cardiology, Center of Advanced Cardiac Therapeutics, Roslyn, NY; ‡Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN; §Department of Medicine, Emory University School of Medicine, Atlanta, GA; and ¶Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Disclosure: The authors have no conflicts of interest to report. Correspondence: Constantine E. Kosmas, MD, PhD, 168-24 Powells Cove Boulevard, Beechhurst, NY 11357. E-mail: email@example.com. Cardiology in Review: November/December 2014 - Volume 22 - Issue 6 - p 279-288 doi: 10.1097/CRD.0000000000000006 Buy Metrics Abstract Coronary artery disease (CAD) is the leading cause of death in the United States. Although CAD was formerly considered a lipid accumulation–mediated disease, it has now been clearly shown to involve an ongoing inflammatory response. Advances in basic science research have established the crucial role of inflammation in mediating all stages of CAD. Today, there is convincing evidence that multiple interrelated immune mechanisms interact with metabolic risk factors to initiate, promote, and ultimately activate lesions in the coronary arteries. This review aims to provide current evidence pertaining to the role of inflammation in the pathogenesis of CAD and discusses the impact of inflammatory markers and their modification on clinical outcomes. © 2014 by Lippincott Williams & Wilkins.