Review ArticlesRole of Magnesium in Cardiovascular DiseasesKolte, Dhaval MD, PhD*; Vijayaraghavan, Krishnaswami MD, MS†; Khera, Sahil MD*; Sica, Domenic A. MD‡; Frishman, William H. MD* Author Information From the *Department of Medicine, Division of Cardiology, New York Medical College, Valhalla, NY; †Scottsdale Healthcare, Scottsdale Cardiovascular Center, Scottsdale, AZ; and ‡Department of Medicine & Pharmacology, Division of Nephrology, Virginia Commonwealth University Health System, Richmond, VA. Disclosure: The authors have no conflicts of interest to report. Correspondence: Sahil Khera, MD, Department of Medicine, Munger Pavilion, New York Medical College, Valhalla, NY 10595. E-mail: [email protected]; [email protected]. Cardiology in Review 22(4):p 182-192, July/August 2014. | DOI: 10.1097/CRD.0000000000000003 Buy Metrics Abstract Magnesium, the fourth most abundant cation in the human body, is involved in several essential physiological, biochemical, and cellular processes regulating cardiovascular function. It plays a critical role in modulating vascular smooth muscle tone, endothelial cell function, and myocardial excitability and is thus central to the pathogenesis of several cardiovascular disorders such as hypertension, atherosclerosis, coronary artery disease, congestive heart failure, and cardiac arrhythmias. This review discusses the vasodilatory, anti-inflammatory, anti-ischemic, and antiarrhythmic properties of magnesium and its current role in the prevention and treatment of cardiovascular disorders. © 2014 by Lippincott Williams & Wilkins.