Review ArticlesEffects of Antihypertensive Drugs on Arterial StiffnessDudenbostel, Tanja MD*; Glasser, Stephen P. MD†Author Information From the *Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, and †Preventive Medicine and Epidemiology, University of Alabama at Birmingham, Birmingham, AL. Disclosure: The authors have no conflict of interest to report. Correspondence: Tanja Dudenbostel, MD, Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, 933 19th St. South, Community Health Services Building (CHSB), Room 115, Birmingham, AL 35294-2041, USA. E-mail: [email protected]. Cardiology in Review: September/October 2012 - Volume 20 - Issue 5 - p 259-263 doi: 10.1097/CRD.0b013e31825d0a44 Buy Metrics Abstract In this review, we discuss the possible pathophysiological mechanisms and the role of arterial stiffness as a biomarker, a blood pressure–independent predictor of cardiovascular morbidity and mortality. The effects of different antihypertensive drug classes on noninvasively assessed markers of arterial stiffness are also discussed. Current evidence will be reviewed regarding the effect of drugs on arterial stiffness, including the peripheral and central effects of angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, dihydropyridine calcium channel blockers, beta blockers (including vasodilating beta blockers), diuretics, and mineralocorticoid antagonists. © 2012 Lippincott Williams & Wilkins, Inc.