Review ArticleHeparin-Induced Thrombocytopenia in Cardiovascular Patients Pathophysiology, Diagnosis, and TreatmentYoon, Joo Heung MD; Jang, Ik-Kyung MD, PhD Author Information From the Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Correspondence: Ik-Kyung Jang, MD, PhD, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, 55 Fruit st, GRB 800, Boston, MA 02114. E-mail: [email protected]. Cardiology in Review: May 2011 - Volume 19 - Issue 3 - p 143-153 doi: 10.1097/CRD.0b013e318211f7c0 Buy Metrics Abstract Heparin-induced thrombocytopenia is a life-threatening immune-mediated platelet activation condition that can cause arterial and venous thromboembolism. The triggering complex, platelet factor 4/heparin antibody, has several unique immunologic characteristics that have not been well elucidated until recently. In patients undergoing cardiovascular procedures such as percutaneous coronary intervention and coronary artery bypass graft surgery, the prevalence of platelet factor 4/heparin antibody is significantly higher than that in the general population. The acuity and graveness of the thromboembolic phenomenon requires early diagnosis and empirical initiation of treatment, even before confirmatory test results are available. Also, although multiple therapeutic modalities exist, the safety and efficacy of each option depends upon the clinical setting. Therefore, this review will focus on the updated pathophysiology of heparin-induced thrombocytopenia, new diagnostic criteria, and the various treatment options for cardiovascular patients with different conditions. © 2011 Lippincott Williams & Wilkins, Inc.