Review ArticleNutriceuticals in Cardiovascular Disease: PsylliumPetchetti, Lavanya MD*; Frishman, William H. MD†; Petrillo, Richard MD*; Raju, Kolanuvada MD*Author Information From the *Department of Medicine, Mt. Vernon Hospital, Mt. Vernon, New York and the †Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, New York. Correspondence: William H. Frishman, MD, Department of Medicine, New York Medical College, Munger 263, Valhalla, NY 10595. E-mail: William_Frishman@nymc.edu. Cardiology in Review: May-June 2007 - Volume 15 - Issue 3 - p 116-122 doi: 10.1097/01.crd.0000242964.74467.27 Buy Metrics Abstract In recent years, there has been a growing interest in the use of dietary fiber in health maintenance and disease prevention. A deficiency of fiber in the Western diet may be contributing to the current epidemics of diabetes mellitus, coronary artery disease (CAD), and colonic cancer. The awareness of fiber as a dietary supplement may have contributed to the reported 30% decline in death rate from CAD observed over the past 15 years. Psyllium is a soluble gel-forming fiber that has been shown to bind to the bile acids in the gut and prevent their normal reabsorption, similar to the bile acid sequestrant drugs. Psyllium is useful as an adjunct to dietary therapy (step 1 or step 2 American Heart Association [AHA] diet) in the treatment of patients with mild-to-moderate hypercholesterolemia. In combination with other cholesterol-lowering drugs, such as statins, psyllium provides an added benefit on cholesterol lowering, and is well tolerated and cost-effective. © 2007 Lippincott Williams & Wilkins, Inc.