According to Cohen criteria, the effect sizes (d) within the program (T1–T4) were large, as all dimensions scored over 0.80, except for PF, where the effect was moderate (d = 0.72). The effect sizes of the program are illustrated in Figure 3. From the end of the program (T4) to 1-year follow-up, there was no further effect within SF (d = 0.08), CF (d = −0.10), RF (d = 0.04), and EF (d = −0.06), a small effect within PF (d = 0.40), and a moderate effect in HRQOL (d = 0.70).
Fatigue was significantly (P < .05), strongly, and negatively correlated (ρ between −0.47 and −0.87) to all the other dimensions of EORTC QLQ-C30 at all points of measurements (baseline, T2, T3, T4 and T5), except for CF at T1 and T2 and EF at T2, T4, and T5.
The study participants scored substantially lower (22.1–49.9 points) at baseline than the healthy normal population did,34 where SF, RF, and fatigue showed the highest differences (Table 3). The participants also scored between 4.5 and 34.7 points lower on all dimensions than the cancer population did35 at baseline. Here, SF, fatigue, and CF showed the highest differences. After completing the program (T4), these differences had decreased substantially related to the normal population (0.1–13.8 points). At the end of the program (T4), the participants scored higher than the cancer population did on all dimensions, except for CF (6.4 points lower) and fatigue (3.4 points lower). At 1-year follow-up, the participants scored closer to the normal population (1.1–16.7 points lower) and higher than the cancer population did in all dimensions, except for CF (11.5 points lower) and fatigue (1 point lower).
Changes in Physical Capacity
Results from the objective tests on physical fitness, lung capacity, muscle strength, and BMI are summarized in Table 4. The participants’ physical fitness was 78.9% at baseline and thus substantially lower than that of the normal population (>90%), regardless of age and gender. The participants had a significant (P < .01) increase in physical fitness from baseline to T2, but no further significant increases were observed at T3 or T4. At T3, the participants’ mean score was closer to that of the normal population, but a small nonsignificant decrease occurred from T3 to T4.
The participants’ lung capacity (FEV1) was 83.7% at baseline and within the lower range of that of the normal population (>80% by age and gender).45 There was a significant (P < .05) increase in FEV1 from baseline to T3.
The participants’ muscle strength was within the range of the normal population at baseline. The results indicated no significant increase in right-hand strength from baseline to T2, T3, or T4. There was a significant increase in left-hand strength from baseline to both T3 (P < .05) and T4 (P < .01).
The participants had a mean BMI of 26.1 kg/m2 at baseline, indicating slight overweight. There was a slight but nonsignificant decrease in BMI at the end of the program (T4).
The effect sizes of the physical parameters within the program (T1–T4) were small for left-hand strength (d = 0.47), physical fitness (d = 0.42), and right-hand strength (d = 0.32), but there was no effect on lung capacity (d = 0.00) and BMI (d = −0.04) (see Figure 3).
The results from the participants’ logs indicated that they continued with physical activity while they were at home between the residential stays (Table 5). The mean value for physical activity between T2 and T3 was 276 minutes/week, divided into 4 sessions with a mean intensity of 14 on Borg’s scale.47 Between T3 and T4, the mean value for physical activity was 231 minutes/week, divided into 4 sessions with a mean intensity of 14 on Borg’s scale.
There were no differences in physical outcomes at baseline related to demographic or medical parameters, except for BMI. Here, the male participants scored significantly higher (P < .05) than the female participants did. Body mass index was also negatively correlated to physical fitness (ρ = −0.48, P < .05). Furthermore, there were no significant correlations between the physical parameters and the different dimensions of the EORTC QLQ-C30 at baseline, except for a significant negative correlation between physical fitness and fatigue (ρ = −0.47, P < .05).
To our knowledge, this is the first study to report on a complex rehabilitation program tailored for YACS, focusing on positive health outcomes such as quality of life and physical capacity. The participants reported significant increases in global HRQOL and in all the functional dimensions and a decrease in fatigue within the program. These values were relatively stable at 1-year follow-up. The effect sizes for the EORTC QLQ-C30 dimensions within the program were generally large. Furthermore, significant changes occurred in physical fitness, lung capacity, and left-hand strength, but no changes in right-hand strength or BMI. The effect sizes of the physical parameters ranged from moderate to no effects. In addition to a low dropout rate and a high level of compliance to the program, these results indicate that the program was feasible for YACS with different cancer types after completing cancer treatment.
These results are in line with earlier studies reporting that multidimensional cancer rehabilitation programs generate positive health outcomes such as quality of life and physical capacity.25,28,29,48 However, this study lacked a control group and included a relatively small sample of YACS. Thus, the findings cannot be generalized to the entire population of YACS.33 Furthermore, it cannot be definitely concluded that the intervention caused the improvements. Nevertheless, in the following sections, we will argue that the beneficial effects cannot simply be attributed to passage of time but are likely to be related to the intervention. These results may then shed light upon some important factors that might promote positive health outcomes for YACS.
Needs and Timing
Recent research has identified YACS as a vulnerable group of cancer survivors in need of follow-up and rehabilitation to build capacity for long-term good health and quality of life.1,3,5,21,23 The results from this study seem to confirm this picture, as the participants scored lower at baseline compared with studies of older cancer survivors.32,48 The participants also reported a large impact on HRQOL at baseline compared with the Norwegian norm population34 (22.1–49.9 points lower).43 On the other hand, they scored relatively similar to the cancer population in global HRQOL, PH, and EF (<10 points) but scored even lower in RE, CF, and SF.43
Previous research has found that fatigue and distress are significant contributors to decreased HRQOL, a measure often underestimated by healthcare providers.13,21,24,25,28,30,48 These findings seem to be in line with the results from the present study. The participants reported a high level of fatigue compared with the norm population and the cancer population (Table 3). In addition, there were high correlations between fatigue and the various dimensions of HRQOL throughout the program. According to Ferrell et al,15 a problem within 1 dimension, here fatigue, can affect the overall HRQOL as well as the other dimensions.
It can be argued that the present sample was biased toward self-selection, representing highly impaired YACS. The sample had an overrepresentation of women, but the prevalence of cancer among young adults in Norway is higher in women than in men.49 The sample was, however, representative of both cancer diagnoses and age distribution within this specific group of cancer survivors.49 On the other hand, several researchers explain low outcome effects on HRQOL by baseline levels comparable with the general population norms, consequently underestimating intervention effects.32,50 Thus, there is a new recommendation to target participants in cancer rehabilitation on a needs-based approach requiring a physician’s clearance or prescreening for participation, rather than a “take all comers” approach.30,32,50 This was done in this study, as a physician’s referral was required to confirm the participants’ need for rehabilitation in accordance with legal rights for necessary healthcare.
Research has documented lack of knowledge in survivorship care, particularly in YACS,5,6,24 along with a limited focus on follow-up and rehabilitation.1,6,24 Within both the Cancer Control Continuum31 and the PEACE framework,16 rehabilitation and health promotion are included in the phases after completion of cancer treatment. This is in line with Courneya and Friedenreich,16 who recommend that the period of rehabilitation and health promotion should start 3 to 6 months after treatment, when the acute effects of medical treatments have dissipated and the person is attempting to resume normal activity. In contrast to this, several studies of cancer rehabilitation have evaluated “mixed” groups of cancer survivors, both undergoing treatment and having finished treatment, which may have affected the results.30,48,50 Consequently, Speck et al30 underline the importance of having the Cancer Control Continuum and PEACE framework to guide cancer rehabilitation research, allowing for greater specificity in evaluating interventions. Thus, the participants in this study had all completed treatment within the last 16 months. Research has revealed that improvement in the first year after cancer treatment is especially important to avoid a prolonged experience of poor HRQOL.19,20,21 The participants’ low baseline levels of HRQOL may therefore indicate that their natural recovery was unsuccessful and that their need for rehabilitation had not been acknowledged early enough to prevent severe impact on HRQOL.24 Furthermore, these results demonstrate the importance of being aware of YACS HRQOL throughout cancer treatment as well as in survivorship care. Screening of HRQOL may thus be a tool to detect areas of resources as well as areas in need of follow-up.
In this study, the participants scored lower than the norm population in HRQOL. They also scored lower or within the lower range of normal for physical capacity. Here, HRQOL was self-reported and the physical parameters were objective tests. One may therefore claim that the objective tests gave a more reliable and “true” picture of the YACS’ present situation. In contrast, it may be argued that the low HRQOL scores indicate that the participants perceived themselves as worse than they really were. Research has revealed that YACS compare their present situation with how they used to be before cancer treatment.6,24 In line with this, Davis8 explains decreased HRQOL as a difference between individuals’ hope and expectations in their life. On the other hand, the physical tests in this study were short and intensive, with a maximum of 6 minutes.44 These tests may then not reflect the respondents’ existent fatigue, as they were able to perform for a short time but experienced fatigue over a long time.24 Furthermore, the objective tests were isolated physical parameters, whereas the HRQOL measures give a picture of the different dimensions in relation to each other.8,14 In line with the findings from this study, other studies have found modest correlations between the dimensions of HRQOL and physical parameters, indicating that physiological parameters and perceptual ratings are relatively independent.13 Katz et al13 argue that HRQOL measures are not proxies for physiological parameters but rather provide a more comprehensive evaluation of patient functioning across multiple life domains, and therefore, they are both needed.
Based on the discussion above, it seems likely that this study’s sample was tailored to a needs base, as all the participants were in the same phase of rehabilitation. Furthermore, the self-reported HRQOL results and the objective physical tests may be seen as more complementary than overlapping. All these factors may thus be important to explain the positive results of this study.
A Real Change or Improvement With Time?
The results indicated significant increases in both HRQOL and some of the physical parameters within the program. The effect sizes in the different dimensions of HRQOL were, in general, high, with smaller effect sizes within physical capacity. For the HRQOL dimensions, the values were rather stable at 1-year follow-up.
These results are considerably higher than those reported in other studies of cancer rehabilitation.10,19,48,50 Thus, some may wonder about the differences between the effect sizes of HRQOL and the physical parameters. According to Crosby et al,14 these differences must be seen in connection with the baseline values because improvements are greater for individuals who have lower scores at baseline, which was the case for HRQOL, and somewhat lesser for higher baseline, as for the physical parameters.
The largest significant changes in the HRQOL dimensions (see Figure 2) and physical fitness occurred during the first residential stay (T1–T2), whereas the significant changes in the other physical parameters occurred after 3 months (Table 4). These results may support the suggestion that the improvements were related to the intervention, and not the passage of time. Theories of empowerment and coping highlight that empowering and developing coping skills are dependent on being in a setting that facilitates interaction, authentic coping experiences, social modeling, social support, as well as knowledge.11,12 The results then may indicate that a residential stay of 3 weeks can be important to initiate the rehabilitation process.
Rehabilitation is defined as a process over time.8 The results illustrate this point as outlined in Figure 2. Whereas the main effects occurred from T1 to T2, there was a steady increase onto T3, T4, and to some extent, onto T5. The participants’ physical parameters were within or close to the norm at the end of the program (T4), and they scored higher than the cancer population did in most of the HRQOL dimensions. In addition, they scored closer to the mean of the norm population than the cancer population did in global HRQOL, PF, and EF, indicating recovery.14 However, in the other dimensions (RF, CF, SF and fatigue), they scored closer to the mean of the cancer population, indicating that fatigue was still a problem.
Theories of rehabilitation stress that processes of change are in need of both time and follow-up.8 New research also documents that cancer survivors are in need of survivorship care and follow-up, especially the YACS.5,6,39 In line with this time and process perspective, the results from this study may indicate that the restays and professional follow-up were important elements of the rehabilitation program. This is supported by Hauken et al,40 who found that YACS highlighted multidimensional follow-up over time as 1 of the most important factors for reaching their rehabilitation goals and increasing participation in all areas of life.
Previous research has found limited durability of beneficial effects in HRQOL and physical capacity from rehabilitation interventions over time. However, most of these studies had short interventions and did not include a 1-year follow-up.10,19,25 In contrast, the findings from this study indicate that the improvements in HRQOL were maintained or even slightly improved at 1-year follow-up (Figure 2 and Table 3). Here, the participants were closer to the normal population (1.1–16.7 points lower) and scored better than the cancer population did in all dimensions, except for CF (11.5 points lower) and fatigue (1 point lower). These results indicate an improvement related to the program.14,43 The small to moderate effect sizes from the end of the program (T4) to the 1-year follow-up also support that the main improvements seem to be related to the intervention. The increases in outcomes after the intervention may be related to the possibility that the participants could cope with and had more control over their cancer related challenges and were thus empowered.11,12 This is supported by a previous study wherein YACS stated that they were not fully rehabilitated at the end of the program but could continue with the rehabilitation process by themselves because they knew how to cope and in which direction to continue.40
Because this study included a small sample size and no control group, several efforts were made to establish valid results.14,16,34 To reduce the likelihood of type 2 errors,33 we used an instrument (EORTC QLQ-C30) with established validity and reliability. Furthermore, the same person conducted the objective measures of physical parameters under the same conditions each time. The intervention was standardized, theory based, and supervised to secure that all the participants got the same program.33 Furthermore, the study had several points of measurement, which also enhances the validity.33 In analyzing the data, nonparametric tests were used and the significance level was set to P < .05, and a number of variables known to be associated with HRQOL were controlled.34 All these efforts indicate that the results are valid. Furthermore, Gray33 argues that finding large effect sizes within a small sample indicates that the changes cannot simply be explained by selection errors. Based on the arguments outlined above, it seems plausible that the beneficial changes in HRQOL and physical parameters are not simply attributable to the passage of time but are likely to be related to the intervention.
Which Elements Were Important?
Even if complex rehabilitation is warranted, it may not be possible to determine the effects of the individual elements of the program on the outcomes.20,25,32 This criticism affects this study as well. However, combining the results with theory and earlier research may offer some indication for important core elements of complex rehabilitation programs tailored for YACS.
SETTING INDIVIDUAL GOALS
According to theory and definitions of rehabilitation, rehabilitation is a goal-oriented process.8,10,31 Applying this theory into clinical practice, research has documented that assisting cancer survivors in setting achievable goals supports the process of health restoration and leads to improved outcomes.8,37,38 In line with this, Hauken et al24 found that YACS expressed that setting specific goals helped them to structure, motivate, and take responsibility for their rehabilitation process. The results revealed high goal achievement and increased participation and satisfaction in all areas of life. The experience of coping and control seemed to mediate the goal-oriented process.40 It therefore seems plausible to argue that setting individual goals within different areas of daily life may help YACS to specify and direct their efforts in the rehabilitation process and build coping capacities.
Physical activity is the single most studied element in cancer rehabilitation, showing physiological and psychological benefits in addition to reducing cancer recurrence risk and mortality.25,30 Research has shown that YACS are interested in programs targeting physical activity, that they prioritize physical goals but are in need of physical activity interventions to meet public guidelines.36,39,40 It seems that the results from this study fit into this picture: Significant improvements and large changes occurred within global HRQOL and all the physical and psychological dimensions of HRQOL, as well as a reduction in fatigue and significant improvement in physical fitness. These results may be explained in accordance with Ferrell et al,15 who state that an intervention directed to 1 dimension, in this case physical activity, may also have positive effects on the other dimensions. Given this study’s results together with the high compliance (>95%) to the exercise sessions, it seems that the content and conduct of physical activity in this program were relevant, feasible, and effective for YACS. Another important finding is that the participants continued with physical exercise between the residential stays at a surprisingly high level considering their reported fatigue at both T3 and T4 (Tables 3 and 4). In fact, physical activity with a mean value of 231.4 minutes in 4 sessions a week indicates physical activity in excess of the guidelines for physical activity for cancer survivors of at least 150 minutes a week.16 Furthermore, a perceived mean intensity of 14 using the Borg scale indicates 75% effort and a level expected to be effective in improving physical capacity and to give positive health effect.18,47 Thus, it may be suspected that the participants overreported their activity in the logs sent to the rehabilitation center. This is not very likely because the logs were filled out in a very detailed and specific way. The participants also knew that they would be tested on the restays and that cheating in the logs would most likely have been discovered. Thus, these results indicate that even fatigued cancer survivors can follow physical exercise guidelines when they get a safe and tailored exercise program.30 This also highlights the importance of healthcare providers focusing on and establishing physical activity guidelines throughout the treatment, which may prevent decreases in physical capacity and HRQOL.16
Research within cancer rehabilitation indicates that both psychoeducation and use of CT are important elements of complex cancer rehabilitation.25,27,39 The theoretical base of psychoeducation and CT is to empower individuals by providing them with knowledge and decision-making skills that are important in enabling them to cope with their present health situation.7,8,11,12 Thus, the tailored psychoeducative program focusing on relevant aspects of YACS such as exercising and how to handle fatigue and return to work/studies may explain some of the positive improvements on the typical psychological dimensions such as CF and EF, as well as the other dimensions (Table 3 and Figure 2). These results are also in line with the framework of Ferrell et al15 indicating that psychoeducation may increase function in all dimensions. Furthermore, these results are also supported by a previous study wherein the participants reported that the psychoeducation provided them with new insight important for their control and coping.40
Rehabilitation is an individual process.8 Research has demonstrated that YACS have multifaceted challenges and needs in survivorship, emphasizing the importance of basing the rehabilitation process on individual needs.4,5,27,39 The participants’ individual needs were addressed in several ways in this study. First, the participants had individual appointments with different cancer rehabilitation specialists, including a physician, a physiotherapist, a nurse, a nutritionist, and a social worker, for a holistic appraisal of needs. All participants attended all appointments, indicating that they found these relevant (see Table 2). The individual perspective was also apparent in the setting and follow-up of personal goals, physical testing, and tailoring and supervision of the exercise program, as well as related to the participant logs. Therefore, it seems likely that the participants’ individual needs were identified, which also may have affected the different dimensions of HRQOL15 in a positive way.
Even if rehabilitation is defined as an individual process,8 empowerment12 and cognitive theory11 identify social support as an important factor in facilitating coping and control and, thus, HRQOL. Some studies have reported that YACS experience an impaired social life after cancer treatment related to late effects and a lack of understanding from their surroundings.5,24 The results from this study are in line with these findings, as the score in SF was the lowest at baseline and the one with the highest improvement at the end of the program (Table 4). Earlier research provides strong evidence that peer support is especially important for YACS.1,5,22 Cancer in young adulthood is rare, and the outpatient regimens of most treatments leave most YACS with limited peer support during treatment.2,24 The participants in this study interacted closely at the rehabilitation stays. They participated in most of the elements of the program together, and they lived, ate, and spent their spare time together. The sharing of experiences from both the cancer journey and the rehabilitation process most likely facilitated close interaction. Previous research has also shown that peer support between cancer survivors has given positive effects on psychosocial function and HRQOL, as well as fostered supportive exchanges and empowerment.41
Contrary to the findings from the other elements of the program, no impact from the next-of-kin weekend can be substantiated, as compliance with this element was only 45%. However, this result may reflect the vulnerability of YACS related to their period of life.5 Some participants did not want their parents to be involved in their rehabilitation process, regardless of whether they lived with their parents or lived alone; some had only recently formed a relationship with a partner and found it difficult to invite them; and the partners of others who had small children experienced practical difficulties in participating.
Even if it is plausible to assume that most of the individual elements of the program accounted for some of the improvements in both HRQOL and physical capacity, it is more likely that the combination of these elements facilitated the positive changes. As the challenges of cancer survivorship are complex, rehabilitation must also be complex. According to the multidimensionality of the definitions of both rehabilitation8 and HRQOL13 and to the framework of HRQOL and survivorship of Ferrell et al,15 it is likely that the different elements had different significance for the YACS based on their individual needs. According to Davis,8 the different elements in the intervention may also have facilitated more congruence between the participants’ hope and expectations and their actual life and thus promoted their HRQOL.
Norway, like several Nordic countries, has an official healthcare system and formal legislation to secure rehabilitation needs.10 This implies that there are limited financial implications for YACS to participate in rehabilitation programs, and health insurance is not required.10 However, the situation is not the same in other countries, where such rehabilitation programs may be unaffordable for YACS because they lack health insurance. Nevertheless, the results from this study seem to point out several important elements of rehabilitation targeted to YACS. These elements may also be effective in other countries and can be implemented in other clinical settings such as primary healthcare as well as in follow-up clinics.
Conclusions and Implications for Clinical Practice and Research
The findings of this study seem to confirm previous research showing YACS to be a vulnerable group of cancer survivors with highly affected HRQOL and impaired physical capacity. The results showed significant increases and large improvements in the different dimensions of HRQOL, as well as significant increases within physical capacity during the program. The participants’ HRQOL was close to the norm population at the end of the program and at 1-year follow up. These results suggest that a complex cancer rehabilitation program especially tailored for YACS may be important in building positive health outcomes, such as HRQOL and physical capacity, over time. Important elements of such a program seem to include setting individual goals, physical exercise, peer support, psychoeducation based on CT, and individual follow-up. The main changes within this study occurred within the program, mainly from T1 to T2. These results suggest that a residential rehabilitation component may be of importance to initiate the rehabilitation process but still acknowledge that cancer rehabilitation is a process requiring time and professional follow-up.
The findings outlined in this study are of significance to clinicians, as healthcare providers should be aware of the symptom burden and HRQOL of YACS throughout the cancer journey. Monitoring YACS’ own perceptions of their HRQOL and symptom burden can help patients to communicate concerns to healthcare providers that might not be otherwise discussed. Although not all YACS will need complex rehabilitation, screening for HRQOL may be valuable for detecting resources and a tool to provide holistic survivorship care. Furthermore, screening for HRQOL (and especially fatigue) seems to be a tool for discovering those in need of special medical attention and complex rehabilitation interventions. The results also pinpoint the importance of including multidimensional interventions to improve HRQOL and physical activity into survivorship care. Awareness of the same elements in the period of cancer treatment may also be beneficial to prevent decrease in HRQOL and physical capacity for YACS.
Because this study’s sample size was small, the results cannot be generalized to the entire population of YACS. However, this study represents a promising starting point for cancer rehabilitation interventions for YACS. Further research should try to illuminate the use of regular screening of HRQOL as well as physical capacity to identify YACS in need of complex rehabilitation based on cutoff values. Complex cancer rehabilitation should target YACS in need, with a suggested start of the rehabilitation phase 3 to 6 months after treatment. Furthermore, randomized controlled trial studies should be conducted to see if the considerable improvements within HRQOL in this study could be confirmed by larger representative samples. Important areas to focus on are the content and structure of the rehabilitation program. To understand the rehabilitation process of YACS better, explorative and qualitative studies within this field are highly warranted.
The authors thank the study respondents for resiliently participating and sharing their profound experiences. Thanks to RCHRC employees for running the program so carefully according to the protocol, especially Kari Fismen for coordinating the project and Per Lønning Kallevik for performing the physical testing. Thanks to Haugland International Research Centre for their profound support.
1. Coccia PF, Altman J, Bhatia S, et al. Adolescent and young adult oncology. J Natl Compr Canc Netw. 2012; 10 (9): 1112–1150.
2. Bleyer A. Young adult oncology: the patients and their survival challenges. Cancer J Clin. 2007; 57 (4): 242–255.
3. Tai E, Buchanan N, Townsend J, Fairley T, Moore A, Richardson LC. Health status of adolescent and young adult cancer survivors
. Cancer. 2012; 118 (19): 4884–4891.
4. Woodward E, Jessop M, Glaser A, Stark D. Late effects in survivors of teenage and young adult cancer: does age matter? Ann Oncol. 2011; 22 (12): 2561–2568.
5. Albritton K, Caliguiri M, Anderson B, Nichols C, Ulman D, Adams H. Closing the Gap: Research and Care Imperatives for Adolescents and Young Adults With Cancer. Bethesda, MD: Department of Health and Human Services, National Institute of Health, National Cancer Institute, and the LiveStrong Young Adult Alliance; 2006.
6. Hewitt ME. From Cancer Patient to Cancer Survivor: Lost in Transition. Washington, DC: The National Academies Press; 2006.
7. WHO. Milestones in Health Promotion. Statements From Global Conferences. Geneva, Switzerland: WHO; 2009.
8. Davis S. Rehabilitation. The Use of Theories and Models in Practice. London, England: Elsevier Limited; 2006.
9. Allen D, Carlson D, Ham C. Well-being: new paradigms of wellness-inspiring positive health outcomes
and renewing hope. Am J Health Promot. 2007; 21 (3): 1–9.
10. Hellbom M, Bergelt C, Bergenmar M, et al. Cancer rehabilitation: a Nordic and European perspective. Acta Oncol. 2011; 50 (2): 179–186.
11. Bandura A. Social cognitive theory: an agentic perspective. Annu Rev Psychol. 2001; 52 (1): 1–26.
12. Zimmerman MA, Warschausky S. Empowerment theory for rehabilitation research: conceptual and methodological issues. Rehabil Psychol. 1998; 43 (1): 3–16.
13. Katz ER, Burnwinkle T, Varni JW, Ronald DB. Health-related quality of life
. In: Bleyer AW, Barr RD, eds. Cancer in Adolescents and Young Adulthood. Berlin, Germany: Springer; 2007: 387–396.
14. Crosby RD, Kolotkin RL, Williams GR. Defining clinically meaningful change in health-related quality of life
. J Clin Epidemiol. 2003; 56 (5): 395–407.
15. Ferrell BR, Hassey Dow K, Grant M. Measurement of the quality of life in cancer survivors. Qual Life Res. 1995; 4 (6): 523–531.
16. Courneya K, Friedenreich C. Framework PEACE: an organizational model for examining physical exercise across the cancer experience. Ann Behav Med. 2001; 23 (4): 263–272.
17. Byers T, Nestle M, McTiernan A, et al. American Cancer Society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. Cancer J Clin. 2002; 52 (2): 92–119.
18. Schmitz KH, Holtzman J, Courneya KS, Mâsse LC, Duval S, Kane R. Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomark Prev. 2005; 14 (7): 1588–1595.
19. May AM, Korstjens I, van Weert E, et al. Long-term effects on cancer survivors’ quality of life of physical training versus physical training combined with cognitive-behavioral therapy: results from a randomized trial. Support Care Cancer. 2009; 17 (6): 653–663.
20. Hjermstad MJ, Knobel H, Brinch L, et al. A prospective study of health-related quality of life
, fatigue, anxiety and depression 3–5 years after stem cell transplantation. Bone Marrow Transplant. 2004; 34 (3): 257–266.
21. Roper K, McDermott K, Cooley ME, Daley K, Fawcett J. Health-related quality of life
in adults with Hodgkin’s disease: the state of the science. Cancer Nurs. 2009; 32 (6): E1–E17. 10.1097/NCC.1090b1013e3181aa1094a1033.
22. Mattson MR, Demshar RK, Daly BJ. Quality of life of young adult survivors of hematologic malignancies. Cancer Nurs. 2013; 36 (2): 1–7.
23. Hall AE, Boyes AW, Bowman J, Walsh RA, James EL, Girgis A. Young adult cancer survivors
’ psychosocial well-being: a cross-sectional study assessing quality of life, unmet needs, and health behaviors. Support Care Cancer. 2012; 20 (6): 1333–1341.
24. Hauken MA, Larsen TM, Holsen I. Meeting reality: young adult cancer survivors
’ experiences of reentering everyday life after cancer treatment. Cancer Nurs. 2013; 36 (5): E17–E26.
25. Juvet LK, Elvsaas IK, Leivseth G, et al. Rehabilitation of Breast Cancer Patients: A Systematic Review. Oslo, Norway: Norwegian Knowledge Centre for the Health Services; 2009.
26. Ugolini D, Neri M, Cesario A, et al. Scientific production in cancer rehabilitation grows higher: a bibliometric analysis. Support Care Cancer. 2012; 20 (8): 1629–1638.
27. Thorsen L, Gjerset GM, Loge JH, et al. Cancer patients’ needs for rehabilitation services. Acta Oncol. 2011; 50 (2): 212–222.
28. Strauss-Blasche G, Gnad E, Ekmekcioglu C, Hladschik B, Marktl W. Combined inpatient rehabilitation and spa therapy for breast cancer patients: effects on quality of life and CA 15-3. Cancer Nurs. 2005; 28 (5): 390–398.
29. van Weert E, Hoekstra-Weebers J, Grol B, et al. A multidimensional cancer rehabilitation program for cancer survivors: effectiveness on health-related quality of life
. J Psychosom Res. 2005; 58 (6): 485–496.
30. Speck R, Courneya K, Mâsse L, Duval S, Schmitz K. An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Survivorship. 2010; 4 (2): 87–100.
32. Petersson LM. Group Rehabilitation for Cancer Patients: Effects, Patient Satisfaction, Utilisation and Prediction of Rehabilitation Need [article based]. Uppsala, Sweden: Department of Public Health and Caring Science, Section for Caring Science, Uppsala University; 2003.
33. Gray D. Doing Research in the Real World. 2nd ed. London, England: Sage Publications Ltd; 2009.
34. Hjermstad MJ, Fayers PM, Bjordal K, Kaasa S. Health-related quality of life
in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: the QLQ=C30 (+3). J Clin Oncol. 1998; 16 (3): 1188–1196.
35. Scott NW, Fayers PM, Aaronson NK, et al.on behalf of the EORTC Quality of Life Group. EORTC QLQ-C30
Reference Values. Brussels, Belgium: Quality of Life Department, EORTC Headquarters; 2008.
36. Rabin C. Review of health behaviors and their correlates among young adult cancer survivors
. J Behav Med. 2011; 34 (1): 41–52.
37. Johansson E, Larsen J, Schempp T, Jonsson L, Winterling J. Patients’ goals related to health and function in the first 13 months after allogeneic stem cell transplantation. Support Care Cancer. 2012; 20 (9): 2025–2032.
38. Locke EA, Latham GP. New directions in goal-setting theory. Curr Dir Psychol Sci. 2006; 15 (5): 265–268.
39. Zebrack B. Information and service needs for young adult cancer patients. Support Care Cancer. 2009; 16 (12): 1353–1360.
40. Hauken MA, Holsen I, Fismen E, Larsen TMB. Participating in life again: a mixed-method study on a goal-oriented rehabilitation program for young adult cancer survivors
[published online ahead of print July 15, 2013]. Cancer Nurs. doi:10.1097/NCC.0b013e31829a9add.
41. Snyder KA, Pearse W. Crisis, social support, and the family response: exploring the narratives of young breast cancer survivors. J Psychosoc Oncol. 2010; 28 (4): 413–431.
42. Aaronson NK, Ahmedzai S, Bergman B, et al. The European-Organization-for-Research-and-Treatment-of-Cancer QLQ-C30—a quality-of-life instrument for use in international clinical-trials in oncology. J Natl Cancer Inst. 1993; 85 (5): 365–376.
43. Fayers PM, Aaronson NK, Bjordal K, Groenvold M, Curran D, Bottomley Aon behalf of the EORTC Quality of Life Group. The EORTC QLQ-C30
Scoring Manual. Brussels, Belgium: European Organisation for Research and Treatment of Cancer; 2001.
44. Åstrand PO, Rodahl K. Textbook of work physiology. New York, NY: McGraw Hill; 1986.
45. Light RW. Clinical pulmonary function testing, exercise testing, and disability evaluation. In George RB, Light RWB, Matthay MA, Matthay RA, eds. Chest Medicine: Essentials of Pulmonary and Critical Care Medicine. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005: 90–112.
46. Massy-Westropp N, Rankin W, Ahern M, Krishnan J, Hearn TC. Measuring grip strength in normal adults: reference ranges and a comparison of electronic and hydraulic instruments. J Hand Surg [Am ]. 2004; 29 (3): 514–519.
47. Borg G. Psychophysical bases of perceived exertion. Med Sci Sports Exerc. 1982; 14 (5): 377–381.
48. Kjaer TK, Johansen C, Ibfelt E, et al. Impact of symptom burden on health related quality of life of cancer survivors in a Danish cancer rehabilitation program: a longitudinal study
. Acta Oncol. 2011; 50 (2): 223–232.
49. Grimsrud TK. Cancer in Norway 2010. Special Issue: Clustering of Cancer. Oslo, Norway: Cancer Registry of Norway. 2012.
50. Johansson B, Brandberg Y, Hellbom M, et al. Health-related quality of life
and distress in cancer patients: results from a large randomized study. Br J Cancer. 2008; 99: 1975–1983.
Keywords:© 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins
Complex rehabilitation; EORTC QLQ-C30; Follow-up; Health-related quality of life; Longitudinal study; Physical fitness; Positive health outcomes; Young adult cancer survivors