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Nursing Interventions to Reduce Peripherally Inserted Central Catheter Occlusion for Cancer Patients

A Systematic Review of Literature

Pan, Mengting, RN; Meng, Aifeng, RN; Yin, Rong, PhD; Zhi, Xiaoxu, RN; Du, Shizheng, RN; Shi, Ruchu, RN; Zhu, Ping, RN; Cheng, Fang, RN; Sun, Mengqing, RN; Li, Cheng, RN; Fang, Hong, RN

doi: 10.1097/NCC.0000000000000664
Article: PDF Only

Background Cancer patients are considered the most at risk of the consequences of catheter occlusion. Therefore, nursing interventions that can effectively reduce the occlusion of peripherally inserted central catheter (PICC) lines must be identified to ensure a smooth treatment.

Objective This study aimed to evaluate nursing interventions to minimize PICC line occlusion and make recommended measures for preventing or decreasing occlusion and abnormal extubation.

Methods Studies about PICC occlusion that were published up to January 2017 were searched and screened in PubMed, Web of Science, Science Direct (Elsevier), EMBASE, Cochrane Library, and Chinese databases CNKI and Wanfang. Two independent reviewers screened the literature in accordance with the inclusion and exclusion criteria, assessed the quality of the included studies, and extracted the data. Further meta-analysis was performed using RevMan 5.3.

Results Thirteen trials were included. Meta-analysis revealed that education for nurses (relative risk, 0.31; 95% confidence interval, 0.19–0.51; P < .00001) was significantly associated with PICC occlusion, whereas PICC type (relative risk, 0.60; 95% confidence interval, 0.32–1.15; P = .12) was not significantly associated with PICC occlusion. The solution to washing pipes and the PICC insertion techniques were descriptively analyzed to reach statistical significance.

Conclusion This study determined the correlation of PICC occlusion with the nurses’ knowledge and skills, PICC types, flushing liquid and methods, and insertion techniques.

Implications for Practice The findings of this study can serve as a guide for clinical work and for developing targeted measures to reduce occlusion.

Author Affiliations: School of Nursing, Nanjing University of Chinese Medicine (Mss Pan, Li, and Fang and Mr Du); and Department of Nursing (Mss Meng and Zhu), Outpatient Clinic (Mss Zhi, Shi, and Cheng), Thoracic Surgery (Dr Yin), and General Surgery (Breast Tumours) (Ms Sun), Jiangsu Cancer Hospital, Nanjing, Jiangsu Province, China.

The authors have no funding or conflicts of interest to disclose.

Correspondence: Aifeng Meng, RN, Department of Nursing, Jiangsu Cancer Hospital, 42 Baiziting Road, Xuanwu District, Nanjing, Jiangsu Province 210009, China (

Accepted for publication August 17, 2018.

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