Institutional members access full text with Ovid®

Share this article on:

Relief of Radiation-Induced Oral Mucositis in Head and Neck Cancer

Putwatana, Panwadee DSc (Nutrition), RN; Sanmanowong, Phichanee MNS, RN; Oonprasertpong, Ladawal DNS, RN; Junda, Tiraporn PhD, RN; Pitiporn, Supaporn BSc, PhD; Narkwong, Ladawan MD

doi: 10.1097/01.NCC.0000343362.68129.ed

This study was a prospective, randomized clinical trial carried out to explore the efficacy of payayor in the prevention and relief of radiation-induced oral mucositis compared with benzydamine. Sixty patients with head and neck cancer, who have started to receive radiotherapy and met predetermined criteria, were randomly assigned into each group to use assigned products 3 times a day from the first to the last day of radiation. The first group used glycerin payayor, a Thai prepared herbal product, by dripping it into the mouth. Another group rinsed their mouths with benzydamine hydrochloride. The World Health Organization Mucositis Grading System was used to assess oral status every week and 2 weeks after radiation. Comparison of time to the onset, pain, severity, xerostomia, postponement of treatment, satisfaction of the solution, and body weight between the 2 groups was performed by t test. The average time to the onset of oral mucositis in the payayor group was significantly later, and its severity and pain score were less than those of the benzydamine group throughout the study period. Significantly higher satisfaction with the solution and higher body weight at the end of the study were shown in the payayor group. Payayor seemed to be superior to benzydamine for preventing and relieving radiation-induced oral mucositis.

Authors' Affiliations: Department of Nursing (Drs Putwatana, Oonprasertpong, and Junda and Ms Sanmanowong), and Department of Radiology (Dr Narkwong), Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chao Phraya Abhaibhubejhr Hospital, Prajeenburi, Thailand (Dr Pitiporn).

This research was supported by Chao Phraya Abhaibhubejhr Foundation.

Corresponding author: Panwadee Putwatana, DSc (Nutrition), RN, Department of Nursing, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Rajthevee, Bangkok 10400, Thailand (

Accepted for publication May 18, 2008.

© 2009 Lippincott Williams & Wilkins, Inc.