ARTICLESCaregivers of Advanced Cancer Patients Feelings of Hopelessness and DepressionMystakidou, Kyriaki MD, PhD; Tsilika, Eleni BSc, MSc; Parpa, Efi BA, MA; Galanos, Antonis BSc; Vlahos, Lambros MD, PhDAuthor Information From Pain Relief and Palliative Care Unit (Dr Mystakidou, Ms Tsilika, Ms Parpa, and Mr Galanos), and Department of Radiology (Dr Vlahos), Areteion Hospital, School of Medicine, University of Athens, Athens, Greece. Corresponding author: Kyriaki Mystakidou, MD, PhD, Pain Relief and Palliative Care Unit, Department of Radiology, Areteion Hospital, School of Medicine, University of Athens, 27 Korinthias St, 115 26 Athens, Greece (e-mail: [email protected]). Accepted for publication March 7, 2007. Cancer Nursing: September 2007 - Volume 30 - Issue 5 - p 412-418 doi: 10.1097/01.NCC.0000290807.84076.73 Buy Metrics Abstract To investigate whether the advanced cancer patients' caregivers' depression and hopelessness are affected by patients' demographic and clinical characteristics and by caregivers' sociodemographic variables. Moreover, the relation between cancer patients' and caregivers' depression and hopelessness was assessed. One hundred five patients with advanced cancer receiving palliative care and 96 caregivers were enrolled in the study. The patients and their caregivers completed the Beck Depression Inventory and the Beck Hopelessness Scale while researchers recorded data on demographic characteristics, disease status, and treatment regimen. The analysis showed that significant associations were found between patient male sex and caregiver's depression (P = .007) and hopelessness (P = .002), between patient family status and caregiver's depression (P = .031) and hopelessness (P = .001), and between patient radiotherapy treatment and caregiver's hopelessness (P = .017). Moreover, statistically significant correlation was found between patient's and caregiver's depression (P = .041). Generalized estimating equations showed that the patients characteristics that predicted caregivers' hopelessness were family status (P = .017), radiotherapy (P = .025), and the caregiver's relation to patient (P = .059). The findings suggest that caregiver's hopelessness is predicted by cancer patient's characteristics and that patient's depression is correlated to that of caregiver. The findings provide a base for future research. © 2007 Lippincott Williams & Wilkins, Inc.