Original Article: PDF OnlyLobert Sharon R.N. M.S.N. Ph.D.; Correia, John J. Ph.D.Cancer Nursing: February 1992 - p 22-33 Buy Abstract Many agents used in cancer chemotherapy act on a specific phase of the cell cycle and are classified as cell cycle-specific. Some of these cell cycle-specific drugs, the antimitotics, interact with tubulin, the major protein of mitotic spindles, and cause metaphase arrest, thus halting mitosis. Understanding the dynamic processes involved in tubulin polymerization/ depolymerization and how chemotherapeutic agents disrupt these processes is fundamental to understanding and anticipating common adverse effects and planning nursing interventions. © Lippincott-Raven Publishers.