Adverse reactions to systemic amphotericin B therapy include fever and severe chills, joint and muscle pain, nausea and vomiting, electrolyte imbalance, phlebitis at the site of injection, anemia, and nephrotoxicity. Hepatotoxicity and anaphylxis are rare occurences. Strict attention to renal function, serum electrolytes, hematologic status, and method of administration is essential. An understanding of the clinical pharmacology of amphotericin B, in conjunction with proper premedication, allows safe administration of this life-saving therapy with a minimum of patient discomfort.
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